FlyBase Allele Report: Dmel\Ndg[HMJ24142]

General Information

Symbol

Dmel\Ndg^HMJ24142

Species

D. melanogaster

Name

FlyBase ID

FBal0315804

Feature type

allele

Associated gene

Dmel\Ndg

Associated Insertion(s)

Carried in Construct

P{TRiP.HMJ24142}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HMJ24142}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMJ24142

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable, with Scer\GAL4^Act.PU

(Dai et al., 2018)

Phenotype Manifest In

basement membrane | larval stage, with Scer\GAL4^Cg.PA

(Dai et al., 2018)

embryonic/larval fat body | larval stage, with Scer\GAL4^Cg.PA

(Dai et al., 2018)

Detailed Description

Statement

Reference

The expression of Ndg^HMJ24142 under the control of Scer\GAL4^Act.PU leads to normal-looking pupae. Expression under the control of Scer\GAL4^Cg.PA induces basement membrane discontinuity in the larval fat body.

(Dai et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Ndg^HMJ24142, Scer\GAL4^Act.PU, trol^JF03376 has decreased body size | pupal stage phenotype

(Dai et al., 2018)

Ndg^HMJ24142, Scer\GAL4^Act.PU, trol^JF03376 has visible | pupal stage phenotype

(Dai et al., 2018)

Ndg^HMJ24142, Scer\GAL4^Act.PU, trol^JF03376 has lethal - all die before end of P-stage phenotype

(Dai et al., 2018)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of Ndg^HMJ24142 and trol^JF03376 under the control of Scer\GAL4^Act.PU leads to small pupae that do not develop to adulthood, as compared to either single knockdown and wild-type controls; this phenotype is more severe at 30[o]C than at 25[o]C.

(Dai et al., 2018)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

62902