FlyBase Allele Report: Dmel\Corp[95B]

General Information

Symbol

Dmel\Corp^95B

Species

D. melanogaster

Name

FlyBase ID

FBal0316247

Feature type

allele

Associated gene

Dmel\Corp

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Chakraborty et al., 2015)

Mutagen

P-element activity

(Chakraborty et al., 2015)

Progenitor genotype

P{EPgy2}CG1632^EY03495

(Chakraborty et al., 2015)

Cytology

Description

Imprecise excision of the progenitor P{EPgy2}CG1632^EY03495 insertion, resulting in a deletion (coordinates X:8269857..8271938 , release 6 genome) which removes the entire Corp coding sequence.

(Chakraborty et al., 2015)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:8,269,857..8,271,938 [-]

Comment:

A 2082 bp deletion resulting from the imprecise excision of P{EPgy2}CG1632^EY03495 is reported to map to X:8269857..8271938 (Release 6 coordinates).

(Chakraborty et al., 2015)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Chakraborty et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

Corp^95B enhances the eye ablation phenotype resulting from an irreparable DNA double-stranded break in the BARTL (Bar and Telomere Loss) assay, such that the eye is completely ablated.

Ionising radiation induced apoptosis is significantly enhanced in homozygous wing discs compared to irradiated controls.

(Chakraborty et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Corp^95B is an enhancer of visible phenotype of p53^GMR.Ex

(Chakraborty et al., 2015)

Corp^95B is an enhancer of increased cell death phenotype of p53^GMR.Ex

(Chakraborty et al., 2015)

Phenotype Manifest In

Enhancer of

Statement

Reference

Corp^95B is an enhancer of eye phenotype of p53^GMR.Ex

(Chakraborty et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

p53^5A-1-4 is epistatic to Corp^95B in the BARTL (Bar and Telomere Loss) assay; double mutant flies have almost wild-type eyes in this assay, indicating suppression of the eye ablation phenotype resulting from an irreparable DNA double-stranded break, as occurs in p53^5A-1-4 single mutants.

p53^5A-1-4 suppresses the increase in irradiation-induced apoptosis seen in Corp^95B mutant flies, with the double mutant phenotype being indistinguishable from that of p53^5A-1-4 single mutants.

Corp^95B enhances the increased cell death and reduced eye phenotypes caused by expression of p53^GMR.Ex.

(Chakraborty et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Corp^95B

corp^95B

(Chakraborty et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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