FlyBase Gene Report: Dmel\Corp

General Information

Symbol

Dmel\Corp

Species

D. melanogaster

Name

Companion of reaper

Annotation Symbol

CG10965

Feature Type

protein_coding_gene

FlyBase ID

FBgn0030028

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Summary

Companion of reaper (Corp) is a gene that is transcriptionally induced following DNA damage. It may function to inhibit the pro-apoptotic activity of the transcriptional factor encoded by p53. [Date last reviewed: 2018-10-11] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

7E1-7E1

Sequence location

X:8,269,898..8,271,409 [-]

Recombination map

1-23

RefSeq locus

NC_004354 REGION:8269898..8271409

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (3 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables p53 binding

inferred from physical interaction with FLYBASE:p53; FB:FBgn0039044

(Chakraborty et al., 2015)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

inferred from genetic interaction with FLYBASE:p53; FB:FBgn0039044

(Chakraborty et al., 2015)

involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

inferred from mutant phenotype

(Chakraborty et al., 2015)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Corp for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W3G9)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Corp-RA

FBtr0071179

NM_132240

1084

213

Corp-RB

FBtr0307283

NM_001258649

1216

213

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Corp-PA

FBpp0071127

24.6

213

7.86

FBpp0298284

24.6

213

7.86

Q9W3G9

NP_001245578

AFH07292

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

213 aa isoforms: Corp-PA, Corp-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9W3G9

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Corp using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Corp_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.45

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

Comment: rapidly degraded

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

embryonic stage 7 -- 8

yolk nucleus

(Fisher et al., 2012)

embryonic stage 9 -- 10

yolk nucleus

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

pupal stage

salivary gland

(Lee et al., 2003)

Additional Descriptive Data

The expression of this gene along with several others is induced in salivary glands in pupae at the time of head eversion. This stage is characterized by an increase in the ecdysone titer as well as large amounts of cell death in this tissue.

(Lee et al., 2003)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Corp in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Corp

View exonic expression by tissue for Dmel\Corp

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030028

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31764/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030028

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030028

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030028

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10965

Flygut - An atlas of the Drosophila adult midgut

FBgn0030028

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Corp

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Corp

Transgenic constructs containing regulatory region of Corp

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene partially disrupted in

Df(1)CRIMIC-CR71553

(Gene Disruption Project members, 2018-)

Inferred from location ( 11 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Corp^GD7148

viable

Corp^95B

viable, with Scer\GAL4^Mef2.PR

Corp^GD7148

Other Phenotypes

Allele

some die during pupal stage, with Scer\GAL4^pnr-MD237

Corp^GD7148

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (0)

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Corp. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Corp - AnxB10

experimental knowledge based

(Guruharsha et al., 2011)

Corp - CG15717

experimental knowledge based

(Guruharsha et al., 2011)

Corp - CG7675

experimental knowledge based

(Guruharsha et al., 2011)

Corp - Dera

experimental knowledge based

(Guruharsha et al., 2011)

Corp - p53

pull down, autoradiography, anti tag coimmunoprecipitation, anti tag western blot, western blot

(Chakraborty et al., 2015)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

hid

suppressible

Corp

(Chakraborty et al., 2015)

p53

suppressible

Corp

(Chakraborty et al., 2015)

p53

enhanceable

Corp

(Chakraborty et al., 2015)

rpr

suppressible

Corp

(Chakraborty et al., 2015)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58225

DroID - A comprehensive database of gene and protein interactions.

FBgn0030028

MIST (genetic) - An integrated Molecular Interaction Database

31764

MIST (protein-protein) - An integrated Molecular Interaction Database

31764

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-23

Cytogenetic map

7E1-7E1

Sequence location

X:8,269,898..8,271,409 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

7E1-7E1

Limits computationally determined from genome sequence between P{EP}CG1632^EP1583 and P{EP}Moe^EP1652

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-23

(FlyBase, 2016)

1-22.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

15650

y¹ w^67c23 P{EPgy2}CG1632^EY03495

86092

w¹¹¹⁸ PBac{WH}Corp^f03996 CG1632^f03996

86109

w¹¹¹⁸ PBac{WH}Corp^f06123 CG1632^f06123

606745

y¹ w^* Df(1)CRIMIC-CR71553 TI{KozakGAL4}Corp^{CR71553-KO-kG4}

10858

11374

v102751

v16130

w¹¹¹⁸; P{GD7148}v16130/CyO

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (13)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH26991

Other clones

DPiM_GH26991

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0030028

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0030028

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Corp protein negatively regulates p53 protein levels. Since Corp has been previously identified as a transcriptional target of p53, Corp thus produces a negative feedback loop on p53.

(Chakraborty et al., 2015)

Overexpression of Corp suppresses DNA damage-induced apoptosis in the soma, but promotes elimination of cells with broken-and-healed chromosomes in the germline.

(Chakraborty et al., 2015)

Relationship to Other Genes

Source for database merge of

Additional comments

Source for identity of Corp CG10965 was sequence comparison ( date:031206 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Corp CG10965

(FlyBase, 1996-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

CG10965

(Keleman et al., 2009.8.5, Zhang et al., 2008, Brodsky et al., 2004, Lee et al., 2003)

Corp

(Cruz et al., 2026, Sanchez et al., 2019, Gene Disruption Project members, 2018-, Kavi et al., 2015, Vartiainen et al., 2014, Chen et al., 2013, Akdemir et al., 2007)

corp

(Ojha and Tapadia, 2020, Chakraborty et al., 2015, Zhang et al., 2008)

Name Synonyms

Companion of reaper

(Cao et al., 2007)

companion of reaper

(Chakraborty et al., 2015, Zhang et al., 2008, Neal et al., 2006)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 38 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31764

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W3G9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9W3G9

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W3G9

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030028

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31764/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030028

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030028

FlyMine - An integrated database for Drosophila genomics

FBgn0030028

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG10965

MARRVEL_MODEL - MARRVEL (model organism gene)

31764

Linkouts

BioGRID - A database of protein and genetic interactions.

58225

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0030028

DroID - A comprehensive database of gene and protein interactions.

FBgn0030028

DRSC - Results frm RNAi screens

FBgn0030028

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Corp_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030028

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0030028

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10965

Flygut - An atlas of the Drosophila adult midgut

FBgn0030028

MIST (genetic) - An integrated Molecular Interaction Database

31764

MIST (protein-protein) - An integrated Molecular Interaction Database

31764

References (37)

The following external sites may use different assemblies or annotations than FlyBase.

-0.45

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