FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mfrnUAS.cNa
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General Information
Symbol
Dmel\mfrnUAS.cNa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct of Navarro
FlyBase ID
FBal0316438
Feature type
allele
Associated gene
Dmel\mfrn
Associated Insertion(s)
Carried in Construct
P{UAS-mfrn.N}
Key Links
Transgenic product class
wild_type
(Navarro et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Navarro et al., 2015)
Mutagen
in vitro construct
(Navarro et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-mfrn.N}
Cytology
Description

UASt regulatory sequences drive expression of full length mfrn.

(Navarro et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
mfrn
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Friedreich ataxia
      modeled by fhRNAi.UAS.cLa
      (Navarro et al., 2015)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      mfrnUAS.cNa/Scer\GAL4repo.PU is an enhancer of abnormal locomotor behavior phenotype of Scer\GAL4repo.PU, fhRNAi.UAS.cAa

      (Navarro et al., 2015)

      Scer\GAL4Act5C.PU/mfrnUAS.cNa is an enhancer of short lived | nutrition conditional phenotype of fhRNAi.UAS.cLa

      (Navarro et al., 2015)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of mfrnScer\UAS.cNa enhances the reduction in lifespan seen when fhdsRNA.Scer\UAS.cLa is expressed under the control of Scer\GAL4Act5C.PU in response to elevated dietary iron. Aconitase activity is unaffected. Lifespan reduction is also enhanced on normal food.

      Expression of mfrnScer\UAS.cNa enhances the motor defects and increased brain vacuolization observed in flies expressing fhdsRNA.IR.Scer\UAS under the control of Scer\GAL4repo.PU.

      (Navarro et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      mfrnScer\UAS.cNa
      mfrnUAS.cNa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct of Navarro
      Secondary FlyBase IDs
        References (1)