FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Vap33unspecified
Open Close
General Information
Symbol
Dmel\Vap33unspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0316757
Feature type
allele
Associated gene
Dmel\Vap33
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Mutant adults have severe mitochondrial morphology defects in the indirect flight muscles (IFMs); 84% lack lamellar cristae, while 7% are enlarged and highly aberrant. The myofibrils of the IFMs appear similar to wild type.

        (Han et al., 2012)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Vap33unspecified is rescued by Vap33UAS.cPa/Scer\GAL4C164

        (Han et al., 2012)
        Comments

        Expression of Vap-33AScer\UAS.cPa under the control of Scer\GAL4C164 rescues nearly 100% of the indirect flight muscle mitochondrial defects seen in Vap-33Aunspecified adults.

        (Han et al., 2012)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        Vap-33Aunspecified
        Vap33unspecified
        ΔVAP
        (Han et al., 2012)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)