FlyBase Allele Report: Dmel\Clbn[HMJ23825]

General Information

Symbol

Dmel\Clbn^HMJ23825

Species

D. melanogaster

Name

FlyBase ID

FBal0317248

Feature type

allele

Associated gene

Dmel\Clbn

Associated Insertion(s)

Carried in Construct

P{TRiP.HMJ23825}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HMJ23825}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMJ23825

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^UAS.cLa.EGFP

(Li et al., 2024)

modeled by Hsap\APP^{Δ41-50.UAS.EGFP}

(Li et al., 2024)

exacerbates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\poly-GR^PO-36.UAS

(Park et al., 2021)

ameliorates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\poly-GR^{80.UAS.Tag:FLAG}

(Li et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Clbn^HMJ23825, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PU, Zzzz\poly-GR^PO-36.UAS

(Park et al., 2021)

Clbn^HMJ23825, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PU, Zzzz\poly-PR^PO-36.UAS

(Park et al., 2021)

Other

Statement

Reference

Clbn^HMJ23825, Scer\GAL4^GMR.PU, Zzzz\poly-GR^PO-36.UAS has increased cell death | adult stage phenotype

(Park et al., 2021)

Clbn^HMJ23825, Scer\GAL4^GMR.PU, Zzzz\poly-GR^PO-36.UAS has decreased size | adult stage phenotype

(Park et al., 2021)

Phenotype Manifest In

Enhancer of

Statement

Reference

Clbn^HMJ23825, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\poly-GR^PO-36.UAS

(Park et al., 2021)

Clbn^HMJ23825, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\poly-PR^PO-36.UAS

(Park et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

The expression of Zzzz\poly-GR^PO-36.UAS under the control of Scer\GAL4^GMR.PU induces a eye degeneration phenotype, which is enhanced by the co-expression of Clbn^HMJ23825, leading to a severely deformed eye and necrotic patches.

(Park et al., 2021)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

62402

y¹ v¹; P{TRiP.HMJ23825}attP40/CyO

NIG-Fly

HMJ23825

y¹ v¹; P{TRiP.HMJ23825}attP40/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Clbn^HMJ23825

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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