FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\S6kII+tCH322-75N12
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General Information
Symbol
Dmel\S6kII+tCH322-75N12
Species
D. melanogaster
Name
FlyBase ID
FBal0317405
Feature type
allele
Associated gene
Dmel\S6kII
Associated Insertion(s)
Carried in Construct
PBac{CH322-75N12}
Also Known As
P[RSK]
Key Links
Transgenic product class
genomic_DNA
(Beck et al., 2015)
wild_type
(Beck et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Beck et al., 2015)
wild_type
(Beck et al., 2015)
Mutagen
in vitro construct
(Beck et al., 2015)
Progenitor genotype
Carried in construct
PBac{CH322-75N12}
Cytology
Description

A 20kb genomic fragment (from clone CH322-75N12) encompassing the S6kII gene locus.

(Beck et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
S6kII
Encoded product / tool
S6kII
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      S6kII+tCH322-75N12 partially rescues S6kIIign-Δ58-1

      (Beck et al., 2015)
      Comments

      Expression of S6kII+tCH322-75N12 suppresses the reduction in NMJ size, and reduced number and area of pre-synaptic active zones seen in S6kIIign-Δ58-1 mutants, but does not suppress the reduced number and area of post-synaptic GluRIID fields. The reduction in spontaneous miniature excitatory junctional potential (mini) amplitude is not rescued. Frequency of minis and quantal content (the number of vesicles releases per action potential) are similar to wild type.

      (Beck et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      S6kII+tCH322-75N12
      Name Synonyms
      Secondary FlyBase IDs
        References (2)