FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mipp1KO
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General Information
Symbol
Dmel\Mipp1KO
Species
D. melanogaster
Name
FlyBase ID
FBal0318374
Feature type
allele
Associated gene
Dmel\Mipp1
Associated Insertion(s)
TI{TI}Mipp1KO
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Cheng and Andrew, 2015)
Mutagen
gene targeting by homologous recombination
(Cheng and Andrew, 2015)
Progenitor genotype
Associated Insertion(s)
TI{TI}Mipp1KO
Cytology
Description

The Mipp1 open reading frame has been replaced by a w+* marker.

(Cheng and Andrew, 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mipp1KO/Mipp1KO embryos display tracheal phenotypes, with significantly elongated dorsal trunks and a significantly decreased percentage of dorsal branches fused with their contralateral partners. Mipp1KO/Mipp1KO embryos have a significantly reduced percentage of intercalated dorsal branches and number of filopodia per dorsal branch.

      (Cheng and Andrew, 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The severity of Mipp1KO/Mipp1KO tracheal phenotypes (significantly decreased percentage of dorsal branches fused with their contralateral partners and correctly migrated ganglionic branches) is enhanced in the presence of Df(1)N73/Df(1)N73.

      (Cheng and Andrew, 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Mipp1KO is rescued by Scer\GAL4btl.PS/Mipp1UAS.cCa

      (Cheng and Andrew, 2015)
      Not rescued by

      Mipp1KO is not rescued by Scer\GAL4btl.PS/Mipp1UAS.EGFP

      (Cheng and Andrew, 2015)

      Mipp1KO is not rescued by Mipp1H67A.UAS/Scer\GAL4btl.PS

      (Cheng and Andrew, 2015)

      Mipp1KO is not rescued by Scer\GAL4btl.PS/Mipp1ER.UAS

      (Cheng and Andrew, 2015)
      Comments

      Reduced percentage of intercalated dorsal branches and decreased number of filopodia per dorsal branch in Mipp1KO/Mipp1KO embryos is rescued by Mipp1Scer\UAS.cCa (but not Mipp1H67A.Scer\UAS, Mipp1Scer\UAS.T:Avic\GFP-EGFP or Mipp1ER.Scer\UAS) expression in the trachea (using Scer\GAL4btl.PS driver).

      (Cheng and Andrew, 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mipp1KO
      mipp1KO
      (Cheng and Andrew, 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)