FlyBase Allele Report: Dmel\Axn[UAS.cUa]

General Information

Symbol

Dmel\Axn^UAS.cUa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Unknown

FlyBase ID

FBal0318481

Feature type

allele

Associated gene

Dmel\Axn

Associated Insertion(s)

Carried in Construct

P{UAS-Axn.U}

Also Known As

UAS-axin

Key Links

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-Axn.U}

Cytology

Description

UAS regulatory sequences drive expression of Axn.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Axn

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Dupont et al., 2012)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | adult stage, with Scer\GAL4^nub.PU

(Reim et al., 2014)

visible | adult stage, with Scer\GAL4^salm.E

(Reim et al., 2014)

Phenotype Manifest In

wing margin, with Scer\GAL4^nub.PU

(Reim et al., 2014)

wing margin, with Scer\GAL4^salm.E

(Reim et al., 2014)

Detailed Description

Statement

Reference

Expression of Axn^Scer\UAS.cUa driven by Scer\GAL4^elav.PU does not affect lifespan or photoreceptor number.

(Dupont et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Axn^UAS.cUa, Scer\GAL4^salm.E has visible | adult stage phenotype, suppressible by Ubi-p5E^HMS01881, Scer\GAL4^salm.E

(Reim et al., 2014)

Axn^UAS.cUa, Scer\GAL4^salm.E has visible | adult stage phenotype, suppressible by CSN6^UAS.ORF, Scer\GAL4^salm.E

(Reim et al., 2014)

Enhancer of

Statement

Reference

Axn^UAS.cUa, Scer\GAL4^nub.PU is an enhancer of visible | adult stage phenotype of Scer\GAL4^nub.PU, amls^GD11667

(Reim et al., 2014)

Suppressor of

Statement

Reference

Axn^UAS.cUa, Scer\GAL4^elav.PU is a suppressor | partially of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU

(Dupont et al., 2012)

Axn^UAS.cUa, Scer\GAL4^Eaat1.PR is a suppressor | partially of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^Eaat1.PR

(Dupont et al., 2012)

Axn^UAS.cUa, Scer\GAL4^elav.PU is a suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU

(Dupont et al., 2012)

Axn^UAS.cUa, Scer\GAL4^elav.PU is a suppressor | partially of decreased cell number | adult stage phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU

(Dupont et al., 2012)

Axn^UAS.cUa, Scer\GAL4^repo.PU is a suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo.PU

(Dupont et al., 2012)

Axn^UAS.cUa, Scer\GAL4^repo.PU is a suppressor of bang sensitive phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo.PU

(Dupont et al., 2012)

Axn^UAS.cUa, Scer\GAL4^repo.PU is a suppressor of abnormal neurophysiology | adult stage phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo.PU

(Dupont et al., 2012)

Phenotype Manifest In

Suppressed by

Statement

Reference

Axn^UAS.cUa, Scer\GAL4^salm.E has wing margin phenotype, suppressible by Ubi-p5E^HMS01881, Scer\GAL4^salm.E

(Reim et al., 2014)

Axn^UAS.cUa, Scer\GAL4^salm.E has wing margin phenotype, suppressible by CSN6^UAS.ORF, Scer\GAL4^salm.E

(Reim et al., 2014)

Enhancer of

Statement

Reference

Axn^UAS.cUa, Scer\GAL4^nub.PU is an enhancer of wing margin phenotype of Scer\GAL4^nub.PU, amls^GD11667

(Reim et al., 2014)

Suppressor of

Statement

Reference

Axn^UAS.cUa, Scer\GAL4^elav.PU is a suppressor | partially of eye photoreceptor cell phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav.PU

(Dupont et al., 2012)

Axn^UAS.cUa, Scer\GAL4^repo.PU is a suppressor of dorsal longitudinal indirect flight muscle cell phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo.PU

(Dupont et al., 2012)

Axn^UAS.cUa, Scer\GAL4^repo.PU is a suppressor of giant fiber neuron phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^repo.PU

(Dupont et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Axn^Scer\UAS.cUa significantly partially suppresses the decreased lifespan seen in flies with expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} driven by Scer\GAL4^elav.PU or Scer\GAL4^Eaat1.PR. Co-expression of Axn^Scer\UAS.cUa significantly suppresses the locomotor defects and photoreceptor loss seen in flies with expression of Hsap\HTT^{Q93.ex1p.Scer\UAS} driven by Scer\GAL4^elav.PU. Co-expression of Axn^Scer\UAS.cUa significantly suppresses the locomotor defects and bang sensitivity seen in Scer\GAL4^repo.PU>Hsap\HTT^{Q93.ex1p.Scer\UAS} flies. Co-expression of Axn^Scer\UAS.cUa significantly suppresses neurophysiological defects seen in the giant fiber pathway of 12 day old Scer\GAL4^repo.PU>Hsap\HTT^{Q93.ex1p.Scer\UAS} flies.

(Dupont et al., 2012)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Axn^Scer\UAS.cUa

Axn^UAS.cUa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Unknown

Secondary FlyBase IDs

References (5)

Report Sections

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