Open Close
General Information
Symbol
Dmel\CPT2δ3
Species
D. melanogaster
Name
FlyBase ID
FBal0318504
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

Estimated extent of a 3224 bp deletion resulting from the imprecise excision of P{GSV7}GS21694. The excision is reported to include the 5' UTR and 505aa (methods) or 508aa (results) of the CPT2 coding sequence. This mapping assumes 505 codons have been completely removed.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the progenitor resulting in a 3224bp deletion of the 5' UTR and the first 505 amino acids of the CPT2 ORF.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The majority of CPT2δ3 animals die during the first 3 days after eclosion - very few die during larval or pupal development. Those that survive the immediate post-eclosion period show a severely reduced adult lifespan and are hyper-sensitive to starvation.

Normally fed CPT2δ3 flies are not heaver, but even lighter than controls. Body length is somewhat reduced, but the ratio of weight and size (BMI) is not increased, compared to controls. Motor activity is also unchanged. However, while total body triacylglyceride (TAG) levels are not increased, there is massive accumulation of TAG-filled lipid droplets in the brains and flight muscle in these mutant flies.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Glial-specific (Scer\GAL4repo.PU) expression of CPT2Scer\UAS.cSa reverses brain TAG accumulation and peri-eclosion lethality of CPT2δ3 mutants.

Muscle-specific (Scer\GAL4Mef2.PU), but not fat body (Scer\GAL4cg.PU) or neuronal (Scer\GAL4nSyb.PU), expression of CPT2Scer\UAS.cSa reverses peri-eclosion lethality of CPT2δ3 mutants.

Expression of CPT2Scer\UAS.cSa in cortex glia (Scer\GAL4Akap200-NP2222 or Scer\GAL4nrv2.PU) or astrocyte-like glia (Scer\GAL4Eaat1.PU), but not in ensheathing glia (Scer\GAL4NP6520), reverses peri-eclosion lethality of CPT2δ3 mutants.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
CPT2δ3
Name Synonyms
Secondary FlyBase IDs
    References (1)