FlyBase Allele Report: Hsap\BRD2[UAS.EGFP]

General Information

Symbol

Hsap\BRD2^UAS.EGFP

Species

H. sapiens

Name

FlyBase ID

FBal0318513

Feature type

allele

Associated gene

Hsap\BRD2

Associated Insertion(s)

Carried in Construct

PBac{UAS-huBRD2.EGFP}

Key Links

Transgenic product class

wild_type

(Bagley et al., 2014)

Mutagen

Nature of the Allele

Transgenic product class

wild_type

(Bagley et al., 2014)

Mutagen

Progenitor genotype

Carried in construct

PBac{UAS-huBRD2.EGFP}

Cytology

Description

UAS regulatory sequences drive expression of Hsap\BRD2 that is tagged at the C-terminal end with EGFP.

(Bagley et al., 2014)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\BRD2

Tagged with

EGFP

green fluorescent protein

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^109(2)80

(Bagley et al., 2014)

Phenotype Manifest In

dendrite | third instar larval stage, with Scer\GAL4^109(2)80

(Bagley et al., 2014)

larval multidendritic class III neuron | third instar larval stage, with Scer\GAL4^109(2)80

(Bagley et al., 2014)

Detailed Description

Statement

Reference

Hsap\BRD2^{Scer\UAS.T:Avic\GFP-EGFP} driven by Scer\GAL4^109(2)80 significantly reduces dendritic spike number and branch points (but not branch length) in class III da sensory neurons.

(Bagley et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^109(2)80/Hsap\BRD2^UAS.EGFP is a suppressor | partially of abnormal neuroanatomy | somatic clone | third instar larval stage phenotype of fs(1)h¹¹¹²

(Bagley et al., 2014)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^109(2)80/Hsap\BRD2^UAS.EGFP is a suppressor | partially of dendrite | somatic clone | third instar larval stage phenotype of fs(1)h¹¹¹²

(Bagley et al., 2014)

Scer\GAL4^109(2)80/Hsap\BRD2^UAS.EGFP is a suppressor | partially of larval multidendritic class III neuron | somatic clone | third instar larval stage phenotype of fs(1)h¹¹¹²

(Bagley et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\BRD2^{Scer\UAS.T:Avic\GFP-EGFP} driven by Scer\GAL4^109(2)80 partially suppresses the reduction of dendritic spikes (but not the reduction in primary dendrite branch length or branch points) seen in class III da sensory neuron fs(1)h¹¹¹²/fs(1)h¹¹¹² larval clones.

(Bagley et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\BRD2^{Scer\UAS.T:Avic\GFP-EGFP}

Hsap\BRD2^UAS.EGFP

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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