FlyBase Allele Report: Dmel\fs(1)h[1112]

General Information

Symbol

Dmel\fs(1)h¹¹¹²

Species

D. melanogaster

Name

FlyBase ID

FBal0318511

Feature type

allele

Associated gene

Dmel\fs(1)h

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Bagley et al., 2014)

Mutagen

ethyl methanesulfonate

(Bagley et al., 2014)

Progenitor genotype

Cytology

Description

Small deletion within the second bromodomain, resulting in a premature stop codon which is predicted to result in a truncated protein.

(Bagley et al., 2014)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | first instar larval stage | somatic clone

(Bagley et al., 2014)

abnormal neuroanatomy | somatic clone | third instar larval stage

(Bagley et al., 2014)

lethal

(Bagley et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

fs(1)h¹¹¹²/fs(1)h¹¹¹² da sensory neuron third instar larval clones have a mild but significant decrease in dendrite length (but not branch points) in class I neurons, a significant decrease in dendrite branch points (but not length) in class II neurons, significant decreases in both dendrite length and branch points in class IV neurons, and a small significant reduction in primary dendrite branch length and points as well as almost complete abolition of dendritic spikes in class III neurons compared to wild type.

fs(1)h¹¹¹²/fs(1)h¹¹¹² da class III sensory neuron first instar (48hr after egg laying) larval clones have a significant reduction of dendritic spikes (but no change in primary branch length or number) compared to wild type.

Unlike wild type larvae, fs(1)h¹¹¹²/fs(1)h¹¹¹² clones do not show a significant increase (at 48 versus 96 hours after egg laying) in dendrite spike number of class III da neurons. fs(1)h¹¹¹²/fs(1)h¹¹¹² class III da neuron clones (in larvae 72hr after egg laying) have a significantly increased amount of retracting dendrite spikes and a significantly decreased amount of stable dendrite spikes compared to wild type.

Axon terminals in fs(1)h¹¹¹²/fs(1)h¹¹¹² class III da sensory larval clones are similar to wild type.

(Bagley et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

fs(1)h¹¹¹² has abnormal neuroanatomy | somatic clone | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^109(2)80/Rac1^UAS.cLa

(Bagley et al., 2014)

fs(1)h¹¹¹² has abnormal neuroanatomy | somatic clone | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^109(2)80/Hsap\BRD2^UAS.EGFP

(Bagley et al., 2014)

NOT suppressed by

Statement

Reference

fs(1)h¹¹¹² has abnormal neuroanatomy | somatic clone | third instar larval stage phenotype, non-suppressible by Scer\GAL4^109(2)80/ct^UAS.cUa

(Bagley et al., 2014)

Suppressor of

Statement

Reference

fs(1)h¹¹¹²/fs(1)h¹¹¹² is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Scer\GAL4^109(2)80, ct^UAS.cUa

(Bagley et al., 2014)

NOT Suppressor of

Statement

Reference

fs(1)h¹¹¹²/fs(1)h¹¹¹² is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Rac1^UAS.cLa, Scer\GAL4^109(2)80

(Bagley et al., 2014)

Phenotype Manifest In

Suppressed by

Statement

Reference

fs(1)h¹¹¹² has dendrite | somatic clone | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^109(2)80/Rac1^UAS.cLa

(Bagley et al., 2014)

fs(1)h¹¹¹² has larval multidendritic class III neuron | somatic clone | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^109(2)80/Rac1^UAS.cLa

(Bagley et al., 2014)

fs(1)h¹¹¹² has dendrite | somatic clone | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^109(2)80/Hsap\BRD2^UAS.EGFP

(Bagley et al., 2014)

fs(1)h¹¹¹² has larval multidendritic class III neuron | somatic clone | third instar larval stage phenotype, suppressible | partially by Scer\GAL4^109(2)80/Hsap\BRD2^UAS.EGFP

(Bagley et al., 2014)

NOT suppressed by

Statement

Reference

fs(1)h¹¹¹² has dendrite | somatic clone | third instar larval stage phenotype, non-suppressible by Scer\GAL4^109(2)80/ct^UAS.cUa

(Bagley et al., 2014)

fs(1)h¹¹¹² has larval multidendritic class III neuron | somatic clone | third instar larval stage phenotype, non-suppressible by Scer\GAL4^109(2)80/ct^UAS.cUa

(Bagley et al., 2014)

Suppressor of

Statement

Reference

fs(1)h¹¹¹²/fs(1)h¹¹¹² is a suppressor of dendrite | third instar larval stage phenotype of Scer\GAL4^109(2)80, ct^UAS.cUa

(Bagley et al., 2014)

fs(1)h¹¹¹²/fs(1)h¹¹¹² is a suppressor of larval multidendritic class I neuron | third instar larval stage phenotype of Scer\GAL4^109(2)80, ct^UAS.cUa

(Bagley et al., 2014)

NOT Suppressor of

Statement

Reference

fs(1)h¹¹¹²/fs(1)h¹¹¹² is a non-suppressor of dendrite | third instar larval stage phenotype of Rac1^UAS.cLa, Scer\GAL4^109(2)80

(Bagley et al., 2014)

fs(1)h¹¹¹²/fs(1)h¹¹¹² is a non-suppressor of larval multidendritic class I neuron | third instar larval stage phenotype of Rac1^UAS.cLa, Scer\GAL4^109(2)80

(Bagley et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of ct^Scer\UAS.cUa driven by Scer\GAL4^109(2)80 does not suppress the reduction of dendritic spikes seen in class III da sensory neuron fs(1)h¹¹¹²/fs(1)h¹¹¹² larval clones. Loss of fs(1)h¹¹¹²/fs(1)h¹¹¹² in class I da neuron clones suppresses the increase in dendrite branch points and length and formation of dendritic spike morphology seen in larvae with ct^Scer\UAS.cUa overexpression driven by Scer\GAL4^109(2)80.

Expression of Rac1^Scer\UAS.cLa driven by Scer\GAL4^109(2)80 partially suppresses the reduction of dendritic spikes seen in class III da sensory neuron fs(1)h¹¹¹²/fs(1)h¹¹¹² larval clones. Loss of fs(1)h¹¹¹²/fs(1)h¹¹¹² in class I da neuron clones does not suppress the increase in dendrite branch points seen in larvae with Rac1^Scer\UAS.cLa overexpression driven by Scer\GAL4^109(2)80.

(Bagley et al., 2014)

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\BRD2^{Scer\UAS.T:Avic\GFP-EGFP} driven by Scer\GAL4^109(2)80 partially suppresses the reduction of dendritic spikes (but not the reduction in primary dendrite branch length or branch points) seen in class III da sensory neuron fs(1)h¹¹¹²/fs(1)h¹¹¹² larval clones.

(Bagley et al., 2014)

Complementation and Rescue Data

Partially rescued by

fs(1)h¹¹¹² is partially rescued by Scer\GAL4^109(2)80/fs(1)h^UAS.EGFP

(Bagley et al., 2014)

Comments

Expression of fs(1)h^{Scer\UAS.T:Avic\GFP-EGFP} driven by Scer\GAL4^109(2)80 partially rescues the reduction of dendritic spikes (but not the reduction in primary dendrite branch length and branch points) in class III da sensory neuron fs(1)h¹¹¹²/fs(1)h¹¹¹² larval clones.

Expression of fs(1)h^{Scer\UAS.T:Avic\GFP-EGFP} driven by Scer\GAL4^109(2)80 partially rescues reduced class IV dendrite length and number, and fails to rescue class II reduced branch points or class I reduced dendrite length, seen in fs(1)h¹¹¹²/fs(1)h¹¹¹² larval clones.

(Bagley et al., 2014)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

fs(1)h¹¹¹²

(Bagley et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (1)

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