FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\l(2)eflUASp.Venus
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General Information
Symbol
Dmel\l(2)eflUASp.Venus
Species
D. melanogaster
Name
FlyBase ID
FBal0318517
Feature type
allele
Associated gene
Dmel\l(2)efl
Associated Insertion(s)
Carried in Construct
P{UASp-Venus-CryAB.wt}
Key Links
Transgenic product class
wild_type
(Wójtowicz et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Wójtowicz et al., 2015)
Mutagen
in vitro construct
(Wójtowicz et al., 2015)
Progenitor genotype
Carried in construct
P{UASp-Venus-CryAB.wt}
Cytology
Description

UASp regulatory sequences drive expression of wild-type l(2)efl that is tagged with Venus.

(Wójtowicz et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
l(2)efl
Tagged with
Venus
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of l(2)eflScer\UAS.P\T.T:Avic\GFP-YFP.Venus driven by Scer\GAL4Mef2.PR leads to mild sarcomere organization muscle defects (occasional myofibril misalignment) and significant locomotion defects compared to wild type (though not as severe as with overexpression of l(2)eflR120G.Scer\UAS.P\T.T:Avic\GFP-YFP.Venus) in third instar larvae.

      l(2)eflScer\UAS.P\T.T:Avic\GFP-YFP.Venus/+ alone or overexpression l(2)eflScer\UAS.P\T.T:Avic\GFP-YFP.Venus driven by Scer\GAL4Hand.PA significantly increases systolic diameter and decreases systolic intervals compared to wild type.

      (Wójtowicz et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of l(2)eflScer\UAS.P\T.T:Avic\GFP-YFP.Venus partially rescues irregular actin patterns in muscle with cherKK107518 driven by Scer\GAL4Mef2.PR in third instar larvae.

      (Wójtowicz et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      l(2)eflScer\UAS.P\T.T:Avic\GFP-YFP.Venus
      l(2)eflUASp.Venus
      Name Synonyms
      Secondary FlyBase IDs
        References (1)