FlyBase Allele Report: Hsap\RREB1[UAS.EGFP]

General Information

Symbol

Hsap\RREB1^UAS.EGFP

Species

H. sapiens

Name

FlyBase ID

FBal0318600

Feature type

allele

Associated gene

Hsap\RREB1

Associated Insertion(s)

Carried in Construct

P{UAS-hRREB1.EGFP}

Key Links

Transgenic product class

wild_type

(Ming et al., 2013)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Ming et al., 2013)

Mutagen

in vitro construct

(Ming et al., 2013)

Progenitor genotype

Carried in construct

P{UAS-hRREB1.EGFP}

Cytology

Description

UAS regulatory sequences drive expression of Hsap\RREB1 that is tagged with EGFP.

(Ming et al., 2013)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\RREB1

Tagged with

EGFP

green fluorescent protein

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal oviposition, with Scer\GAL4^GMR44E10

(Deady et al., 2017)

Phenotype Manifest In

egg chamber | oogenesis stage S14, with Scer\GAL4^GMR44E10

(Deady et al., 2017)

oocyte associated follicular epithelium | oogenesis stage S14, with Scer\GAL4^GMR44E10

(Deady et al., 2017)

Detailed Description

Statement

Reference

Females overexpressing Hsap\RREB1^UAS.EGFP under the control of Scer\GAL4^GMR44E10 show a significant increase in egg chamber follicle rupture (ex vivo, octopamine-treated egg chambers) but lay significantly fewer eggs, as compared to controls.

(Deady et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Hsap\RREB1^UAS.EGFP, Scer\GAL4^GMR44E10 is an enhancer of abnormal oviposition phenotype of Scer\GAL4^GMR44E10, peb^GD1507

(Deady et al., 2017)

Suppressor of

Statement

Reference

Hsap\RREB1^UAS.EGFP, Scer\GAL4^GMR44E10 is a suppressor | partially of abnormal oviposition phenotype of Scer\GAL4^GMR44E10, peb^KK107575

(Deady et al., 2017)

Phenotype Manifest In

Suppressor of

Statement

Reference

Hsap\RREB1^UAS.EGFP, Scer\GAL4^GMR44E10 is a suppressor of egg chamber | oogenesis stage S14 phenotype of Scer\GAL4^GMR44E10, peb^GD1507

(Deady et al., 2017)

Hsap\RREB1^UAS.EGFP, Scer\GAL4^GMR44E10 is a suppressor of oocyte associated follicular epithelium | oogenesis stage S14 phenotype of Scer\GAL4^GMR44E10, peb^GD1507

(Deady et al., 2017)

Hsap\RREB1^UAS.EGFP, Scer\GAL4^GMR44E10 is a suppressor of egg chamber | oogenesis stage S14 phenotype of Scer\GAL4^GMR44E10, peb^KK107575

(Deady et al., 2017)

Hsap\RREB1^UAS.EGFP, Scer\GAL4^GMR44E10 is a suppressor of oocyte associated follicular epithelium | oogenesis stage S14 phenotype of Scer\GAL4^GMR44E10, peb^KK107575

(Deady et al., 2017)

Scer\GAL4^c381/Hsap\RREB1^UAS.EGFP is a suppressor | partially of germ band phenotype of peb¹¹⁴²

(Ming et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\RREB1^{Scer\UAS.T:Avic\GFP-EGFP} driven by Scer\GAL4^c381 partially suppresses the failure of germ band retraction seen in peb¹¹⁴²/y mutant embryos.

(Ming et al., 2013)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\RREB1^{Scer\UAS.T:Avic\GFP-EGFP}

Hsap\RREB1^UAS.EGFP

RREB-1^EGFP

(Ming et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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