FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Tcs31A19
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General Information
Symbol
Dmel\Tcs31A19
Species
D. melanogaster
Name
FlyBase ID
FBal0318697
Feature type
allele
Associated gene
Dmel\Tcs3
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Lin et al., 2015)
Progenitor genotype
Cytology
Description

Amino acid replacement: D201N.

(Lin et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:16,352,715..16,352,715 [+]
Nucleotide change:

G16352715A

Amino acid change:

D201N | Tcs3-PA

Reported amino acid change:

D201N

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Lin et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Compared to wild type (pupate around day 5, eclose around day 10), Tcs31A19/Df(3L)ED220 exhibit an extended larval period prior to lethality (viability: 100% at day 8, 50% at day 16) and have melanotic masses ('black spots': 70% at day 8, 100% at day 16); larvae are unable to dig into food.

      (Lin et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Tcs37A6

      (Lin et al., 2015)

      Tcs37A9

      (Lin et al., 2015)

      Tcs39D1

      (Lin et al., 2015)

      Tcs33A7

      (Lin et al., 2015)
      Rescued by

      Df(3L)ED220/Tcs31A19 is rescued by Tcs3GFP(S65T)

      (Lin et al., 2015)

      Df(3L)ED220/Tcs31A19 is rescued by Tcs3+tLa

      (Lin et al., 2015)
      Comments

      Tcs3T:Avic\GFP-S65T or Tcs3+tLa rescues Tcs31A19/Df(3L)ED220 to adult viability and no melanotic masses are seen in rescued animals.

      (Lin et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      The Tcs31A2 and Tcs31A19 mutant lines are independent isolations of the same lesion in Tcs3 (amino acid replacement D201N) as they were isolated from different chromosomes.

      (Lin et al., 2015)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      1A19
      (Lin et al., 2015)
      Tcs31A19
      Name Synonyms
      Secondary FlyBase IDs
        References (1)