FB2026_02 , released June 18, 2026
Allele: Dmel\ArfipGBD.UAS.Tag:HA
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General Information
Symbol
Dmel\ArfipGBD.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0318746
Feature type
allele
Associated gene
Dmel\Arfip
Associated Insertion(s)
Carried in Construct
P{UAS-Arfip.GBD.HA}
Key Links
Transgenic product class
missense_variant
(Chang et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Chang et al., 2015)
Mutagen
in vitro construct
(Chang et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-Arfip.GBD.HA}
Cytology
Description

UASt regulatory sequences drive expression of Arfip, which has been mutated to abolish binding of small GTPases without altering membrane binding (contains the amino acid replacements H170A, Q172A and H173A in the GTPase binding pocket). The protein is tagged with Tag:HA.

(Chang et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Arfip
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      ArfipGBD.UAS.Tag:HA/Scer\GAL4RapGAP1-OK6 fails to rescue Arfip71/Arfip12

      (Chang et al., 2015)

      Scer\GAL4elav-C155/ArfipGBD.UAS.Tag:HA fails to rescue Arfip71/Arfip12

      (Chang et al., 2015)
      Comments

      Expression of ArfipGBD.Scer\UAS.T:Ivir\HA1 driven by either Scer\GAL4elav-C155 or Scer\GAL4RapGAP1-OK6 does not rescue the reduced bouton number seen at the neuromuscular junction of Arfip12/Arfip71 third instar larvae.

      (Chang et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ArfipGBD.Scer\UAS.T:Ivir\HA1
      ArfipGBD.UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)