FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mip1
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General Information
Symbol
Dmel\Mip1
Species
D. melanogaster
Name
FlyBase ID
FBal0319149
Feature type
allele
Associated gene
Dmel\Mip
Associated Insertion(s)
TI{TI}Mip1
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Min et al., 2016)
Mutagen
ends-out gene targeting
(Min et al., 2016)
Progenitor genotype
Associated Insertion(s)
TI{TI}Mip1
Cytology
Description

The entire Mip coding sequence has been deleted and replaced with a w+mW.hs marker.

(Min et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mip1/Mip1 or Mip1/Df(3L)BSC432 male and female flies show significant increases in body weight (13%) and food intake (25%) compared to controls; abdominal fat storage is significantly increased in Mip1/Mip1 adults compared to controls. Activating Scer\GAL4Mip.PM neurons leads to decreases in BW, but no change in BW is seen with the additional presence of Mip1/Mip1. Mip1/Mip1 flies show significant increases in attraction to food odors compared to controls. Mip1/Mip1 flies show elevated proboscis extension responses to sucrose solution (after 0 but not 18hr starvation), compared to controls.

      (Min et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Mip1 is rescued by Scer\GAL4Mip.PM/MipUAS.cMa

      (Min et al., 2016)
      Comments

      Expression of MipScer\UAS.cMa driven by Scer\GAL4Mip.PM rescues the increases in body weight, food intake, abdominal fat, attraction to food odors and proboscis extension responses seen in Mip1/Mip1 flies.

      (Min et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mip1
      (Fernandez-Acosta et al., 2025, Jang et al., 2017)
      mip1
      (Min et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)