FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\kugΔTMICR.EGFP
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General Information
Symbol
Dmel\kugΔTMICR.EGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0319178
Feature type
allele
Associated gene
Dmel\kug
Associated Insertion(s)
Carried in Construct
P{fat2-EGFP.ΔTMICR}
Key Links
Transgenic product class
inframe_deletion
(Aurich and Dahmann, 2016)
Mutagen
    Nature of the Allele
    Transgenic product class
    inframe_deletion
    (Aurich and Dahmann, 2016)
    Mutagen
    Progenitor genotype
    Carried in construct
    P{fat2-EGFP.ΔTMICR}
    Cytology
    Description

    Genomic fragment containing kug (coordinates 3L:19998559..20035492 ) in which the transmembrane region and the intracellular region has been replaced by a EGFP-FNF-3xFLAG tagging cassette.

    (Aurich and Dahmann, 2016)
    Allele components
    Component
    Use(s)
    Regulatory region(s)
    kug
    Encoded product / tool
    kug
    Tagged with
    EGFP
    Tag:FLAG
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Fails to rescue

        kugΔTMICR.EGFP fails to rescue kug58D

        (Aurich and Dahmann, 2016)
        Comments

        Expression of kugΔTMICR.T:Avic\GFP-EGFP in kug58D mutants fails to restore normal elongation and rotation of egg chambers or normal oviposition. It also fails to rescue the disrupted subcellular localization of actin, microtubule and collagen IV fibers in the extracellular matrix of the follicle epithelium.

        (Aurich and Dahmann, 2016)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        fat2ΔTMICR-GFP
        (Chen et al., 2017)
        kugΔTMICR.EGFP
        kugΔTMICR.T:Avic\GFP-EGFP
        Name Synonyms
        Secondary FlyBase IDs
          References (2)