FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\TpnC4F2-3
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General Information
Symbol
Dmel\TpnC4F2-3
Species
D. melanogaster
Name
FlyBase ID
FBal0319225
Feature type
allele
Associated gene
Dmel\TpnC4
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Adame et al., 2016)
Mutagen
CRISPR/Cas9
(Adame et al., 2016)
Progenitor genotype
Cytology
Description

12bp deletion plus a 1bp insertion near the 5' end of the TpnC4 coding region. This is predicted to produce a polypeptide consisting of the first 6 amino acids of TpnC4 followed by 5 amino acids and a stop codon.

(Adame et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2R:5,506,769..5,506,780 [-]
Comment:

12 base deletion and one base insertion (T) in the coding sequence of TpnC4 leads to a frameshift and early translation termination.

Inserted_sequence:

T

(Adame et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      TpnC4F2-3 homozygous adults display significant decrease in their jumping ability (reduced jump distance) and are completely flightless.

      (Chechenova et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      TpnC4F2-3
      (Chechenova et al., 2017)
      TpnCF2-3
      (Adame et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)