FlyBase Gene Report: Dmel\TpnC4

General Information

Symbol

Dmel\TpnC4

Species

D. melanogaster

Name

Troponin C isoform 4

Annotation Symbol

CG12408

Feature Type

protein_coding_gene

FlyBase ID

FBgn0033027

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Summary

Troponin C isoform 4 (TpnC4) encodes a calcium-binding subunit in the troponin complex of flight muscle. Together with the other troponin subunits, it activates the muscle when it is stretched, leading to rapid oscillatory contractions. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

TnC4, TnC, DmTpnCIIIb, DmTnC4

Key Links

Genomic Location

Cytogenetic map

41F2-41F3

Sequence location

2R:5,503,437..5,507,866 [-]

Recombination map

2-55

RefSeq locus

NT_033778 REGION:5503437..5507866

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (3 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables calcium ion binding

inferred from electronic annotation with InterPro:IPR002048

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables enzyme regulator activity

inferred from biological aspect of ancestor with PANTHER:PTN000549861

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in flight

inferred from mutant phenotype

(Adame et al., 2016)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

TROPONIN C ISOFORMS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

TROPONIN C ISOFORMS -: The troponin complex associates with tropomyosin (Tm1) and controls the contraction of the striated muscle in response to changes in intracellular calcium concentration. Troponin C (TpnC) is the calcium-binding subunit of the troponin complex and, in insects, is encoded by multiple genes. (Adapted from FBrf0184125.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\TpnC4 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.41

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

TpnC4-RA

FBtr0086075

NM_136329

849

153

TpnC4-RB

FBtr0302019

NM_001169584

746

153

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

TpnC4-PA

FBpp0085411

17.0

153

4.20

NP_610173

AAF57327

TpnC4-PB

FBpp0291229

17.0

153

4.20

NP_001163055

ACZ94335

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

153 aa isoforms: TpnC4-PA, TpnC4-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\TpnC4 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

TpnC4_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

pcr

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage -- adult stage

organism

(Qiu et al., 2003)

Additional Descriptive Data

Expression of TpnC4 was not detected in embryos. Expression was detected in larva and persisted throughout development and into adult stages. Expression was high in the adult body.

(Qiu et al., 2003)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

indirect flight muscle

(Chechenova et al., 2017)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

indirect flight muscle

(Chechenova et al., 2017, Qiu et al., 2003)

Additional Descriptive Data

Expression of this troponin isoform is specific to IFM.

(Chechenova et al., 2017)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{TpnC4-lacZ.1.3}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

indirect flight muscle

(Chechenova et al., 2017)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\TpnC4 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\TpnC4

View exonic expression by tissue for Dmel\TpnC4

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0033027

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0033027

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG12408-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12408

Flygut - An atlas of the Drosophila adult midgut

FBgn0033027

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of TpnC4

Transgenic constructs containing regulatory region of TpnC4

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2R)BSC696

(Adame et al., 2016)

Inferred from location ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

TpnC4^GD7719

viable, with Scer\GAL4^tin.CΔ4

TpnC4^GD7719

Other Phenotypes

Allele

abnormal jump response

TpnC4^F2-3

abnormal jump response, with Scer\GAL4^Act79B.PB

TpnC4^KK110436

flightless

TpnC4^F2-3

flightless, with Scer\GAL4¹¹⁵¹

TpnC4^KK110436

flightless, with Scer\GAL4^Hk-UH3

TpnC4^GD7719

flightless, with Scer\GAL4^Mef2.PR

TpnC4^GD7719

flightless (with Df(2R)BSC696)

Phenotype manifest in

Allele

indirect flight muscle, with Scer\GAL4^Hk-UH3

TpnC4^GD7719

sarcomere, with Scer\GAL4^Hk-UH3

TpnC4^GD7719

sarcomere, with Scer\GAL4^Mef2.PR

TpnC4^GD7719

Z disc, with Scer\GAL4^Mef2.PR

TpnC4^GD7719

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (53)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CALML6

4 of 15

Yes

Hsap\CALML5

3 of 15

Hsap\CABP4

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Hsap\EFCAB9

2 of 15

Yes

Hsap\AIF1

1 of 15

Yes

Hsap\AIF1L

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\EFCAB11

1 of 15

Hsap\EFCAB12

1 of 15

Yes

Hsap\EFCAB13

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\OCM

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (50)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Calm4

3 of 15

Yes

Mmus\Calm5

3 of 15

Yes

Mmus\1700023F06Rik

2 of 15

Yes

Mmus\Cabp4

2 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

Yes

Mmus\Efcab9

2 of 15

Yes

Mmus\Efcab11

2 of 15

Yes

Mmus\Aif1l

1 of 15

Yes

Mmus\Aif1

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Efcab12

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Rattus norvegicus (Norway rat) (49)

Rnor\Cabp4

2 of 13

Yes

Rnor\Cabp5

2 of 13

Yes

Rnor\Calm1

2 of 13

Yes

Rnor\Calm3

2 of 13

Yes

Rnor\Calml4

2 of 13

Yes

Rnor\Efcab3

2 of 13

Yes

Rnor\LOC100361655

2 of 13

Yes

Rnor\LOC100911628

2 of 13

Yes

Rnor\Aif1l

1 of 13

Yes

Rnor\Aif1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Efcab12

1 of 13

Yes

Rnor\Gca

1 of 13

Rnor\LOC100910474

1 of 13

Rnor\LOC108348197

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (51)

Xtro\cabp4

2 of 12

Yes

Xtro\calm1

2 of 12

Yes

Xtro\aif1l

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\LOC108647597

1 of 12

Xtro\LOC108647647

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\ocm

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\pvalb.2

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (64)

Drer\cabp5a

2 of 15

Yes

Drer\cabp5b

2 of 15

Yes

Drer\calm2b

2 of 15

Yes

Drer\calml4a

2 of 15

Yes

Drer\calml4b

2 of 15

Yes

Drer\aif1l

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\pvalb4

1 of 15

Yes

Drer\pvalb6

1 of 15

Drer\pvalb8

1 of 15

Yes

Drer\pvalb9

1 of 15

Yes

Drer\rhbdl3

1 of 15

Drer\scgn

1 of 15

Drer\si:cabz01076231.1

1 of 15

Yes

Drer\si:ch211-197n1.2

1 of 15

Drer\si:ch211-202f3.3

1 of 15

Drer\si:ch211-202f3.4

1 of 15

Drer\si:dkeyp-50d11.2

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (38)

Cele\tnc-2

6 of 15

Yes

Cele\pat-10

2 of 15

Cele\B0563.7

1 of 15

Cele\bath-25

1 of 15

Yes

Cele\C50C3.5

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\T09B4.4

1 of 15

Cele\Y73C8B.5

1 of 15

Arabidopsis thaliana (thale-cress) (12)

Atha\AT3G25600

2 of 9

Yes

Atha\AT1G18530

1 of 9

Atha\AT1G32250

1 of 9

Atha\AT1G73630

1 of 9

Yes

Atha\AT2G41090

1 of 9

Atha\AT3G03000

1 of 9

Atha\AT3G29000

1 of 9

Yes

Atha\AT4G26470

1 of 9

Atha\CAM8

1 of 9

Atha\CAM9

1 of 9

Yes

Atha\CML11

1 of 9

Atha\MSS3

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (5)

Scer\CMD1

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\cam1

1 of 12

Yes

Spom\cam2

1 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190HSV )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\TpnCIIIb

Drosophila persimilis

Dper\GL15651

Drosophila willistoni

Dwil\GK21946

Drosophila virilis

Dvir\TpnCIIIb

Drosophila mojavensis

Dmoj\GI18875

Drosophila grimshawi

Dgri\GH21732

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150DQX )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17021473

Musca domestica

House fly

Mdoa\17021475

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_07684

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_07683

Mayetiola destructor

Hessian fly

Mdes\Mdes003143

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL006575

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL006572

Anopheles darlingi

American malaria mosquito

Adar\ADAC006323

Anopheles darlingi

American malaria mosquito

Adar\ADAC006309

Anopheles gambiae

Malaria mosquito

Agam\AGAP006181

Anopheles gambiae

Malaria mosquito

Agam\AGAP006182

Anopheles gambiae

Malaria mosquito

Agam\AGAP006179

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ016821

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ012250

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ012251

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0K0R )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA006937

Bombyx mori

Silkmoth

Bmor\BGIBMGA006743

Bombyx mori

Silkmoth

Bmor\BGIBMGA006742

Bombyx mori

Silkmoth

Bmor\BGIBMGA008861

Bombyx mori

Silkmoth

Bmor\BGIBMGA009869

Danaus plexippus

Monarch butterfly

Dple\DPOGS212111-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS213018-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS200878-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL012299

Heliconius melpomene

Postman butterfly

Hmel\HMEL012523

Heliconius melpomene

Postman butterfly

Hmel\HMEL015053

Apis florea

Little honeybee

Aflo\2147512483

Apis florea

Little honeybee

Aflo\2314379300

Apis florea

Little honeybee

Aflo\4286594100

Apis florea

Little honeybee

Aflo\4286594132

Apis florea

Little honeybee

Aflo\2147627043

Apis mellifera

Western honey bee

Amel\GB45174

Apis mellifera

Western honey bee

Amel\GB40619

Apis mellifera

Western honey bee

Amel\GB45211

Apis mellifera

Western honey bee

Amel\GB40618

Apis mellifera

Western honey bee

Amel\GB48216

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP23579

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP19855

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP20048

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP21857

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP20049

Bombus terrestris

Buff-tailed bumblebee

Bter\15205981

Bombus terrestris

Buff-tailed bumblebee

Bter\15211469

Bombus terrestris

Buff-tailed bumblebee

Bter\15205980

Bombus terrestris

Buff-tailed bumblebee

Bter\15210139

Bombus terrestris

Buff-tailed bumblebee

Bter\15211564

Linepithema humile

Argentine ant

Lhum\LH12676

Linepithema humile

Argentine ant

Lhum\LH13999

Linepithema humile

Argentine ant

Lhum\LH21881

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001f76

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00070e

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001800

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0006a4

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG032116

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG005449

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG029990

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG019186

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG002564

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG011404

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_12222

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_05626

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_03086

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_08434

Tribolium castaneum

Red flour beetle

Tcas\TC005470

Tribolium castaneum

Red flour beetle

Tcas\TC006493

Tribolium castaneum

Red flour beetle

Tcas\TC012704

Tribolium castaneum

Red flour beetle

Tcas\TC012196

Pediculus humanus

Human body louse

Phum\PHUM494800

Pediculus humanus

Human body louse

Phum\PHUM369310

Rhodnius prolixus

Kissing bug

Rpro\RPRC012224

Rhodnius prolixus

Kissing bug

Rpro\RPRC007075

Rhodnius prolixus

Kissing bug

Rpro\RPRC014921

Cimex lectularius

Bed bug

Clec\CLEC006709

Cimex lectularius

Bed bug

Clec\CLEC001757

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007392

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI009055

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI000699

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007505

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_04924

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_06448

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_09713

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_13044

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0K6P )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR004800

Strigamia maritima

European centipede

Smar\SMAR011877

Strigamia maritima

European centipede

Smar\SMAR008448

Stegodyphus mimosarum

African social velvet spider

Smim\KFM58477.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM73629.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur29g00800

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_442789

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_442805

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_442804

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0V73 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Odadc3L1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Calm1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Odadc3L2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Calm2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_005036gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_024195gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Calm

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_020033gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Odadc3L3

Ciona intestinalis

Vase tunicate

Cint\LOC494376

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000000627

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000008615

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000008616

Gallus gallus

Domestic chicken

Ggal\CALM

Gallus gallus

Domestic chicken

Ggal\CALML3

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000026445

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (29)

Gene Symbol

Score

Source

Alignment

5 of 10

4 of 10

4 of 10

4 of 10

4 of 10

3 of 10

Cam

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CALML6; calmodulin like 6

4 of 15

610171

CALML5; calmodulin like 5

3 of 15

605183

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

TpnC4 - CG5028

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - CG6330

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - COX5A

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - COX7AL2

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - Gpdh1

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - GstS1

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - Mf

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - Mlc2

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - Tm2

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - fln

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - mAcon1

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - up

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - wupA

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

TpnC4

enhanceable

TpnC41C

(Chechenova et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

TpnC41C

enhanceable

TpnC4

(Chechenova et al., 2017)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

61407

DroID - A comprehensive database of gene and protein interactions.

FBgn0033027

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

35498

MIST (protein-protein) - An integrated Molecular Interaction Database

TpnC4

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-55

Cytogenetic map

41F2-41F3

Sequence location

2R:5,503,437..5,507,866 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

41F2-41F3

Limits computationally determined from genome sequence between P{PZ}vlc⁰⁷⁰²²&P{lacW}l(2)09851^k08138 and P{PZ}l(2)09851⁰⁹⁸⁵¹&P{lacW}Src42A^k10108

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-55

(FlyBase, 2016)

2-55.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Bloomington

81770

y¹ v¹; P{TKO.GS04745}attP40/CyO

63021

y¹ sc^* v¹ sev²¹; P{TRiP.HMS05295}attP40

VDRC

v102031

P{KK110436}VIE-260B

v51741

w¹¹¹⁸; P{GD7719}v51741

v318435

PBac{fTRG00484.sfGFP-TVPTBF}VK00033

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (21)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0033027

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens