FlyBase Gene Report: Dmel\TpnC4

General Information

Symbol

Dmel\TpnC4

Species

D. melanogaster

Name

Troponin C isoform 4

Annotation Symbol

CG12408

Feature Type

protein_coding_gene

FlyBase ID

FBgn0033027

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Troponin C isoform 4 (TpnC4) encodes a calcium-binding subunit in the troponin complex of flight muscle. Together with the other troponin subunits, it activates the muscle when it is stretched, leading to rapid oscillatory contractions. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

TnC4, TnC, DmTpnCIIIb, DmTnC4

Key Links

Genomic Location

Cytogenetic map

41F2-41F3

Sequence location

2R:5,503,437..5,507,866 [-]

Recombination map

2-55

RefSeq locus

NT_033778 REGION:5503437..5507866

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables calcium ion binding

inferred from electronic annotation with InterPro:IPR002048

(InterPro Project Members, 2004-)

Biological Process (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in flight

inferred from mutant phenotype

(Adame et al., 2016)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in centrosome

inferred from biological aspect of ancestor with PANTHER:PTN008588806

(GO Reference Genome Project, 2011-)

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN008588804

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN008588804

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

TROPONIN C ISOFORMS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

TROPONIN C ISOFORMS -: The troponin complex associates with tropomyosin (Tm1) and controls the contraction of the striated muscle in response to changes in intracellular calcium concentration. Troponin C (TpnC) is the calcium-binding subunit of the troponin complex and, in insects, is encoded by multiple genes. (Adapted from FBrf0184125.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\TpnC4 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7K860)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.41

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

TpnC4-RA

FBtr0086075

NM_136329

849

153

TpnC4-RB

FBtr0302019

NM_001169584

746

153

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

TpnC4-PA

FBpp0085411

17.0

153

4.20

FBpp0291229

17.0

153

4.20

Q7K860

NP_001163055

ACZ94335

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

153 aa isoforms: TpnC4-PA, TpnC4-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\TpnC4 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

TpnC4_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.22

Transcript Expression

pcr

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage -- adult stage

organism

(Qiu et al., 2003)

Additional Descriptive Data

Expression of TpnC4 was not detected in embryos. Expression was detected in larva and persisted throughout development and into adult stages. Expression was high in the adult body.

(Qiu et al., 2003)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

indirect flight muscle cell

(Chechenova et al., 2017)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

indirect flight muscle cell

(Chechenova et al., 2017, Qiu et al., 2003)

Additional Descriptive Data

Expression of this troponin isoform is specific to IFM.

(Chechenova et al., 2017)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{TpnC4-lacZ.1.3}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

indirect flight muscle cell

(Chechenova et al., 2017)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\TpnC4 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\TpnC4

View exonic expression by tissue for Dmel\TpnC4

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0033027

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35498/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0033027

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033027

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0033027

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12408

Flygut - An atlas of the Drosophila adult midgut

FBgn0033027

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of TpnC4

Transgenic constructs containing regulatory region of TpnC4

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2R)BSC696

(Adame et al., 2016)

Inferred from location ( 3 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

TpnC4^GD7719

viable, with Scer\GAL4^tin.CΔ4

TpnC4^GD7719

Other Phenotypes

Allele

abnormal jump response

TpnC4^F2-3

abnormal jump response, with Scer\GAL4^Act79B.PB

TpnC4^KK110436

flightless

TpnC4^F2-3

flightless, with Scer\GAL4¹¹⁵¹

TpnC4^KK110436

flightless, with Scer\GAL4^Hk-UH3

TpnC4^GD7719

flightless, with Scer\GAL4^Mef2.PR

TpnC4^GD7719

flightless (with Df(2R)BSC696)

Phenotype manifest in

Allele

indirect flight muscle cell, with Scer\GAL4^Hk-UH3

TpnC4^GD7719

sarcomere, with Scer\GAL4^Hk-UH3

TpnC4^GD7719

sarcomere, with Scer\GAL4^Mef2.PR

TpnC4^GD7719

Z disc, with Scer\GAL4^Mef2.PR

TpnC4^GD7719

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (43)

Hsap\CALML6

5 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

Yes

Hsap\CABP2

2 of 14

Yes

Hsap\CABP5

2 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Hsap\CALN1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\EFCAB7

1 of 14

Yes

Hsap\EFCAB9

1 of 14

Yes

Hsap\EFCAB12

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (28)

Rnor\Calm1

3 of 14

Yes

Rnor\Calm3

3 of 14

Yes

Rnor\Calml3

3 of 14

Yes

Rnor\Cabp5

2 of 14

Yes

Rnor\Calm2

2 of 14

Rnor\Cetn2

2 of 14

Rnor\Cabp1

1 of 14

Yes

Rnor\Cabp2

1 of 14

Rnor\Cabp4

1 of 14

Rnor\Cabp7

1 of 14

Yes

Rnor\Calml4

1 of 14

Rnor\Calm-ps2

1 of 14

Yes

Rnor\Caln1

1 of 14

Yes

Rnor\Cetn1

1 of 14

Rnor\Cetn3

1 of 14

Rnor\Efcab3

1 of 14

Yes

Rnor\Efcab7

1 of 14

Yes

Rnor\Efcab12

1 of 14

Yes

Rnor\Efhd1

1 of 14

Rnor\Efhd2

1 of 14

Rnor\LOC100361655

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Tnnc2

1 of 14

Mus musculus (laboratory mouse) (29)

Mmus\Calm1

3 of 14

Yes

Mmus\Calm2

3 of 14

Yes

Mmus\Calm3

3 of 14

Yes

Mmus\Calm4

3 of 14

Yes

Mmus\Calml3

3 of 14

Yes

Mmus\Cabp5

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Calml4

1 of 14

Mmus\Caln1

1 of 14

Yes

Mmus\Cetn1

1 of 14

Mmus\Efcab3

1 of 14

Yes

Mmus\Efcab7

1 of 14

Yes

Mmus\Efcab9

1 of 14

Yes

Mmus\Efcab12

1 of 14

Yes

Mmus\Efcab15

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (21)

Xtro\calml4

1 of 13

Yes

Xtro\cetn1

1 of 13

Yes

Xtro\chp1

1 of 13

Yes

Xtro\cib1

1 of 13

Yes

Xtro\cib2

1 of 13

Yes

Xtro\dnaaf10

1 of 13

Yes

Xtro\efhd1

1 of 13

Yes

Xtro\efhd2

1 of 13

Yes

Xtro\hpcal1

1 of 13

Yes

Xtro\LOC100493285

1 of 13

Yes

Xtro\mxd3

1 of 13

Yes

Xtro\myl1

1 of 13

Yes

Xtro\myl3

1 of 13

Yes

Xtro\myl6

1 of 13

Yes

Xtro\ncald

1 of 13

Yes

Xtro\ncs1

1 of 13

Yes

Xtro\taf4

1 of 13

Yes

Xtro\tesc

1 of 13

Yes

Xtro\tnnc1

1 of 13

Yes

Xtro\tnnc2

1 of 13

Yes

Xtro\vsnl1

1 of 13

Yes

Danio rerio (Zebrafish) (37)

Drer\cabp5a

3 of 14

Yes

Drer\calm1a

3 of 14

Yes

Drer\calm1b

3 of 14

Yes

Drer\calm2a

3 of 14

Yes

Drer\calm2b

3 of 14

Yes

Drer\calm3a

3 of 14

Yes

Drer\calm3b

3 of 14

Yes

Drer\cabp5b

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\calml4a

1 of 14

Drer\calml4b

1 of 14

Drer\caln1

1 of 14

Yes

Drer\caln2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\efhd1

1 of 14

Drer\efhd2

1 of 14

Drer\LOC100329495

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:cabz01076231.1

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (19)

Cele\tnc-2

5 of 14

Yes

Cele\pat-10

4 of 14

Yes

Cele\B0563.7

1 of 14

Cele\C50C3.5

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (18)

Agam\AgaP_AGAP006181

5 of 12

Yes

Agam\AgaP_AGAP006182

5 of 12

Yes

Agam\AgaP_AGAP006178

4 of 12

Yes

4 of 12

3 of 12

3 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (51)

Atha\AT3G25600

3 of 13

Yes

Atha\AT1G18530

2 of 13

Yes

Atha\AT1G24620

2 of 13

Yes

Atha\AT1G32250

2 of 13

Yes

Atha\AT2G41090

2 of 13

Atha\AT3G03000

2 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT4G26470

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\CDC31

2 of 13

Yes

Scer\CMD1

2 of 13

Yes

Scer\CNB1

1 of 13

Scer\FRQ1

1 of 13

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\cam1

2 of 12

Yes

Spom\cam2

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:TpnC4. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (32)

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

Cam

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

elm

1 of 13

Frq1

1 of 13

Mlc1

1 of 13

Mlc-c

1 of 13

Nca

1 of 13

Swip-1

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CALML6; calmodulin like 6

5 of 14

3 of 14

3 of 14

LONG QT SYNDROME 15; LQT15

long QT syndrome 15

CALM3; calmodulin 3

3 of 14

114183

LONG QT SYNDROME 16; LQT16

long QT syndrome 16

CALML3; calmodulin like 3

3 of 14

114184

CALML5; calmodulin like 5

3 of 14

605183

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

TpnC4 - CG6330

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - COX5A

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - COX7AL2

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - Gpdh1

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - GstS1

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - Idh3g

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - Mf

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - Mlc2

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - Tm2

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - fln

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - mAcon1

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - up

experimental knowledge based

(Guruharsha et al., 2011)

TpnC4 - wupA

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

TpnC4

enhanceable

TpnC41C

(Chechenova et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

TpnC41C

enhanceable

TpnC4

(Chechenova et al., 2017)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

61407

DroID - A comprehensive database of gene and protein interactions.

FBgn0033027

MIST (protein-protein) - An integrated Molecular Interaction Database

35498

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-55

Cytogenetic map

41F2-41F3

Sequence location

2R:5,503,437..5,507,866 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

41F2-41F3

Limits computationally determined from genome sequence between P{PZ}vlc⁰⁷⁰²²&P{lacW}l(2)09851^k08138 and P{PZ}l(2)09851⁰⁹⁸⁵¹&P{lacW}Src42A^k10108

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-55

(FlyBase, 2016)

2-55.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

81770

y¹ v¹; P{TKO.GS04745}attP40/CyO

63021

y¹ sc^* v¹ sev²¹; P{TRiP.HMS05295}attP40

606552

y¹ w^*; TI{CRIMIC.TG4.1}TpnC4^{CR92236-TG4.1} Ugt50B3^{CR92236-TG4.1-X}/SM6a

VDRC

v102031

P{KK110436}VIE-260B

v51741

w¹¹¹⁸; P{GD7719}v51741

v318435

PBac{fTRG00484.sfGFP-TVPTBF}VK00033

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (19)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RH03361

Other clones

FI07231

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0033027

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0033027

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

BB14/7.1

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: TpnC4 BcDNA:RH03361

(FlyBase, 1996-)

Additional comments

Source for identity of TpnC4 CG12408 was sequence comparison ( date:030514 ).

(FlyBase, 1996-)

Source for merge of TpnC4 BcDNA:RH03361 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: TpnC4 CG12408

(FlyBase, 1996-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (21)

Reported As

Symbol Synonym

BcDNA:RH03361

CG12408

(Jiang et al., 2017, Çiçek et al., 2016, Palu and Thummel, 2016, Keleman et al., 2009.8.5, Perkins et al., 2009, McGraw et al., 2004, Myster et al., 2004, Wang et al., 2004, Corradini et al., 2003, Giot et al., 2003, Goldstein and Gunawardena, 2000)

DmTnC4

(Lehmann and Bartussek, 2017, Qiu et al., 2003)

DmTpnC41F

(Herranz et al., 2004)

DmTpnCIIIb

(Herranz et al., 2005, Herranz et al., 2004)

TNC41F6

(Diaz-Castillo and Golic, 2007)

TPnC4

(Bordet et al., 2021)

TnC

(Firdaus et al., 2015, Vikhorev et al., 2010, Nongthomba et al., 2004)

TnC4

(Lehmann and Bartussek, 2017, Firdaus et al., 2015, Singh et al., 2014, Vikhorev et al., 2010, Nongthomba et al., 2007)

Tnc4

(Kollmar, 2006, Kollmar and Odronitz, 2006)

TpnC IIIb

(Herranz et al., 2004)

TpnC41F

(Montana and Littleton, 2006)

TpnCIIIb

(Herranz et al., 2005)

tnC4

(Qiu, 2002.10.23)

tpnc4

(Li et al., 2015)

Name Synonyms

TpnC4

Troponin C 41F

(Pedersen et al., 2010)

Troponin C isoform 4

(Gao et al., 2021, Spletter and Schnorrer, 2014)

Troponin C4

(McGraw et al., 2008)

troponin C

(Vikhorev et al., 2010)

troponin-C

(Firdaus et al., 2015)

Secondary FlyBase IDs

FBgn0047054

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35498

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7K860

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7K860

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0033027

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35498/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0033027

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0033027

FlyMine - An integrated database for Drosophila genomics

FBgn0033027

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG12408

MARRVEL_MODEL - MARRVEL (model organism gene)

35498

Linkouts

BioGRID - A database of protein and genetic interactions.

61407

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0033027

DroID - A comprehensive database of gene and protein interactions.

FBgn0033027

DRSC - Results frm RNAi screens

FBgn0033027

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

BB14/7.1

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

TpnC4_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033027

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0033027

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12408

Flygut - An atlas of the Drosophila adult midgut

FBgn0033027

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0033027

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC012196

MIST (protein-protein) - An integrated Molecular Interaction Database

35498

References (82)

The following external sites may use different assemblies or annotations than FlyBase.

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