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FB2026_01
,
released March 12, 2026
ELC_3, myosin light chain, mlc, ELC2, mlcl
Please see the JBrowse view of Dmel\Mlc1 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.44
Gene model reviewed during 5.53
Low-frequency RNA-Seq exon junction(s) not annotated.
0.95 (northern blot)
155 (aa)
larval and adult myosin alkali light chain
pupal myosin alkali light chain
putative larval form
putative adult flight muscle form
Myosin is a hexamer of 2 heavy chains and 4 light chains.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mlc1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Expression dependent on Mef2 levels.
Mlc1 is enriched in border follicle cells relative to follicle cells.
The larval spliced form of Mlc1 is found in the head muscle (tubular-type muscle) in adults and not in the indirect flight muscle.
The indirect flight muscle is the only tissue that accumulates the alternatively spliced form of Mlc1 mRNA in the adult.
The splice form is found only in late pupae.
Mlc1 transcripts are expressed in late embryos, first, second, and third instars, late pupae, and adults.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Mlc1 in JBrowse
3-94
3-91.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Variation of a microsatellite within the Mlc1 locus has been studied in North American populations of D.melanogaster.
The ATPase activity of phosphorylated and dephosphorylated myosins from adult flies has been determined.
The phosphorylation state and ATPase activity of myosin light chain isoforms has been compared in wild-type and mfd- flies.
The phosphorylation state of a number of different myosin light chain isoforms has been determined.
Tissue-specific splicing of Mlc1 RNA has been studied.
Encodes the myosin alkali light chain (MLC-ALK), so called because it dissociates from MHC only at high pH. Expressed during periods of myogenesis: late embryo, larvae, late pupae and adults; not expressed in early embryos or in early pupae during histolysis of larval muscle.
