FlyBase Gene Report: Dmel\Eip63F-1

General Information

Symbol

Dmel\Eip63F-1

Species

D. melanogaster

Name

Ecdysone-induced protein 63F 1

Annotation Symbol

CG15855

Feature Type

protein_coding_gene

FlyBase ID

FBgn0004910

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

Ecdysone-induced protein 63F 1 (Eip63F-1) encodes a member of the EF-hand family of Ca[2+]-binding proteins, induced directly by 20-hydroxyecdysone in late third instar larvae. It is responsible for formation of the 63F early puff in the polytene chromosomes. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Also Known As

E63-1

Key Links

Genomic Location

Cytogenetic map

63F6-64A1

Sequence location

3L:3,909,973..3,935,617 [-]

Recombination map

3-9

RefSeq locus

NT_037436 REGION:3909973..3935617

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables calcium ion binding

inferred from direct assay

(Andres and Thummel, 1995)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables calcium ion binding

inferred from electronic annotation with InterPro:IPR002048

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000549682

(GO Reference Genome Project, 2011-)

enables enzyme regulator activity

inferred from biological aspect of ancestor with PANTHER:PTN000549861

(GO Reference Genome Project, 2011-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in microtubule cytoskeleton organization

inferred from biological aspect of ancestor with PANTHER:PTN000549862

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Vaskova et al., 2000)

located_in nucleus

inferred from direct assay

(Vaskova et al., 2000)

located_in plasma membrane

inferred from direct assay

(Vaskova et al., 2000)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000549861

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Eip63F-1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P48593)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Eip63F-1-RA

FBtr0073174

NM_080163

1139

193

Eip63F-1-RB

FBtr0303420

NM_001202116

2552

161

Eip63F-1-RC

FBtr0303421

NM_001202117

880

181

Eip63F-1-RD

FBtr0303422

NM_001202118

2777

166

Additional Transcript Data and Comments

Reported size (kB)

2.8, 1.7, 1.1 (northern blot)

(Andres and Thummel, 1995)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Eip63F-1-PA

FBpp0073031

22.0

193

4.50

FBpp0292481

18.5

161

4.15

FBpp0292482

20.6

181

4.38

FBpp0292483

19.1

166

4.17

M9MS04

NP_001189047

ADV37484

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

193 (aa); 22 (kD predicted)

(Andres and Thummel, 1995)

Comments

Eip63F-1 protein was shown to bind Ca²⁺ in an in vitro assay.

(Andres and Thummel, 1995)

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Eip63F-1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.61

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

embryonic/larval fat body

(Andres and Thummel, 1995)

epidermis

(Andres and Thummel, 1995)

larval brain

(Andres and Thummel, 1995)

embryonic/larval salivary gland

(Andres and Thummel, 1995)

larval ventral nerve cord

(Andres and Thummel, 1995)

embryonic/larval midgut

(Andres and Thummel, 1995)

imaginal disc

(Andres and Thummel, 1995)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage & larval stage

(Andres and Thummel, 1995)

embryonic stage 15 -- 17

organism

(Andres and Thummel, 1995)

larval stage

embryonic/larval salivary gland

(Andres and Thummel, 1995)

late third instar larval stage

organism

(Andres and Thummel, 1995)

prepupal stage P1 -- P4

Comment: reference states 0-8 hr APF

(Andres and Thummel, 1995)

pupal stage P7 -- pharate adult stage P15(i)

Comment: reference states 32-96 hr APF

(Andres and Thummel, 1995)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Vaskova et al., 2000)

located_in nucleus

inferred from direct assay

(Vaskova et al., 2000)

located_in plasma membrane

inferred from direct assay

(Vaskova et al., 2000)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Eip63F-1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Eip63F-1

View exonic expression by tissue for Dmel\Eip63F-1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

47878/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004910

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004910

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004910

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG15855

Flygut - An atlas of the Drosophila adult midgut

FBgn0004910

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Eip63F-1

Transgenic constructs containing regulatory region of Eip63F-1

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Eip63F-1^d01762

Sterility

Allele

fertile

Eip63F-1^d01762

Other Phenotypes

Allele

abnormal oxidative stress response

Eip63F-1^MB04523

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (50)

Hsap\CALM1

3 of 14

Yes

Hsap\CALM2

3 of 14

Yes

Hsap\CALM3

3 of 14

Yes

Hsap\CALML3

3 of 14

Yes

Hsap\CALML5

3 of 14

Yes

Hsap\CALML6

3 of 14

Yes

Hsap\CETN1

3 of 14

Yes

Hsap\CETN2

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CALML4

1 of 14

Hsap\CALN1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Hsap\LOC118142757

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\OCM

1 of 14

Yes

Hsap\PEF1

1 of 14

Hsap\PVALB

1 of 14

Yes

Hsap\PVALEF

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (41)

Rnor\Calm1

3 of 14

Yes

Rnor\Calm2

3 of 14

Yes

Rnor\Calm3

3 of 14

Yes

Rnor\Calml3

3 of 14

Yes

Rnor\Cetn2

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

Rnor\Cabp2

1 of 14

Rnor\Cabp5

1 of 14

Rnor\Cabp7

1 of 14

Yes

Rnor\Calml4

1 of 14

Rnor\Caln1

1 of 14

Yes

Rnor\Cetn3

1 of 14

Rnor\Cib2

1 of 14

Rnor\Efcab6

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Pvalb

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (45)

Mmus\Calm1

3 of 14

Yes

Mmus\Calm2

3 of 14

Yes

Mmus\Calm3

3 of 14

Yes

Mmus\Calm4

3 of 14

Yes

Mmus\Calml3

3 of 14

Yes

Mmus\Cetn2

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Calml4

1 of 14

Mmus\Caln1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Pvalb

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (25)

Xtro\cetn1

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (67)

Drer\calm1a

3 of 14

Yes

Drer\calm1b

3 of 14

Yes

Drer\calm2a

3 of 14

Yes

Drer\calm2b

3 of 14

Yes

Drer\calm3a

3 of 14

Yes

Drer\calm3b

3 of 14

Yes

Drer\cetn2

3 of 14

Yes

Drer\cetn4

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\calml4a

1 of 14

Drer\calml4b

1 of 14

Drer\caln1

1 of 14

Yes

Drer\caln2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\pvalb2

1 of 14

Yes

Drer\pvalb3

1 of 14

Yes

Drer\pvalb4

1 of 14

Yes

Drer\pvalb5

1 of 14

Yes

Drer\pvalb6

1 of 14

Yes

Drer\pvalb7

1 of 14

Yes

Drer\pvalb8

1 of 14

Yes

Drer\pvalb9

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:cabz01076231.1

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (23)

Cele\B0563.7

3 of 14

Yes

Cele\cal-2

3 of 14

Yes

Cele\cal-5

3 of 14

Yes

Cele\cmd-1

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (20)

Agam\AgaP_AGAP005378

10 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (74)

Atha\CAM8

3 of 13

Yes

Atha\CAM9

3 of 13

Yes

Atha\CEN2

3 of 13

Yes

Atha\CEN2

3 of 13

Yes

Atha\CML11

3 of 13

Yes

Atha\AT1G18210

2 of 13

Yes

Atha\AT1G73630

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Yes

Atha\AGD11

1 of 13

Yes

Atha\AT1G05990

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT3G25600

1 of 13

Atha\AT3G29000

1 of 13

Yes

Atha\AT3G47480

1 of 13

Yes

Atha\AT3G59440

1 of 13

Yes

Atha\AT4G03290

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\PC1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\CMD1

3 of 13

Yes

Scer\CNB1

2 of 13

Scer\FRQ1

2 of 13

Scer\CDC31

1 of 13

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\cam1

3 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Eip63F-1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (34)

Acam

2 of 13

azot

2 of 13

Cam

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

elm

1 of 13

Frq1

1 of 13

Frq2

1 of 13

LPCAT

1 of 13

Nca

1 of 13

Nox

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 4 )

Human Ortholog

Disease

Evidence

References

CALM1; calmodulin 1

model of long QT syndrome 14

IEA

(FlyBase, 2019-)

model of catecholaminergic polymorphic ventricular tachycardia 4

IEA

(FlyBase, 2019-)

CALM3; calmodulin 3

model of long QT syndrome 16

IEA

(FlyBase, 2019-)

CALM2; calmodulin 2

model of long QT syndrome 15

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

3 of 14

3 of 14

LONG QT SYNDROME 15; LQT15

long QT syndrome 15

CALM3; calmodulin 3

3 of 14

114183

LONG QT SYNDROME 16; LQT16

long QT syndrome 16

CALML3; calmodulin like 3

3 of 14

114184

CALML5; calmodulin like 5

3 of 14

605183

CALML6; calmodulin like 6

3 of 14

3 of 14

3 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

71025

DroID - A comprehensive database of gene and protein interactions.

FBgn0004910

MIST (protein-protein) - An integrated Molecular Interaction Database

47878

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-9

Cytogenetic map

63F6-64A1

Sequence location

3L:3,909,973..3,935,617 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

63F6-64A1

Limits computationally determined from genome sequence between P{PZ}Sc2⁰⁵⁶³⁴ and P{PZ}l(3)rG166^rG166;

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

63F-63F

(determined by in situ hybridisation)

(Andres and Thummel, 1995)

63F-63F

(Andres and Thummel, 1992)

Experimentally Determined Recombination Data

Location

3-9

(FlyBase, 2016)

3-8.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

1803

w^*; P{GawB}Eip63F-1^55B

19164

w¹¹¹⁸; P{XP}Eip63F-1^d01762

80867

y¹, v¹; P{TKO.GS04771}attP40

24716

w¹¹¹⁸; Mi{ET1}Eip63F-1^MB04523

53855

y¹ w^*; Mi{MIC}Eip63F-1^MI10465

56215

y¹ w^*; Mi{MIC}Eip63F-1^MI10540

84203

y¹ v¹; M{WKO.P3-A5}ZH-86Fb/TM3, Sb¹

77808

y¹ w^*; Mi{Trojan-GAL4.1}Eip63F-1^{MI10540-TG4.1}

Kyoto

106513

w^*; P{GawB}Eip63F-1^55B

VDRC

v102809

P{KK112498}VIE-260B

Genomic Clones (28)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (77)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

IP21873

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0004910

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0004910

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Null mutations in Eip63F-1 have no effect on development or fertility.

(Vaskova et al., 2000)

Eip63F-1 encodes a 193 amino acid Ca²⁺-binding protein with four putative Ca²⁺-binding domains. It is most similar to calmodulins with approximately 35% similarity overall. It produces three transcripts of 2.8kb, 1.7kb, and 1.1 kb. All three are induced by ecdysone in the salivary gland, share the same 5' ends and encode the same open reading frame.

(Andres, 1996.1.5)

Molecular analysis of the 63F puff.

(Andres and Thummel, 1995)

Eip63F-1 gene product is induced in late larval salivary glands.

(Andres and Thummel, 1992)

The gene that corresponds to the 63F early ecdysone induced puff.

Relationship to Other Genes

Source for database merge of

Source for merge of: Eip63F-1 CG15855

(Misra, 2000.4.8)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

63F-1

CBP12

(Kollmar, 2006)

CG15855

(Keleman et al., 2009.8.5)

Ca²⁺ binding protein

(Brenman et al., 2001)

E63-1

(Carlson et al., 2022, Costantino et al., 2006, Biyasheva et al., 2001, Do and Andres, 2000, Vaskova et al., 2000, Do and Andres, 1998, Bender et al., 1997, Vaskova and Andres, 1997, Andres and Thummel, 1996, Baehrecke, 1996, Andres and Thummel, 1995)

E63F

(Andres and Thummel, 1992)

Eip63-1

(Jordan et al., 2012)

Eip63F-1

(van der Graaf et al., 2021, Ojha and Tapadia, 2020, Campbell et al., 2019, Meltzer, 2019-, Meltzer et al., 2019, Transgenic RNAi Project members, 2017-, Gene Disruption Project members, 2016-, Xie et al., 2015, Bischof and FlyORF project members, 2014.6.20, Cook et al., 2010.2.12, Nagoshi et al., 2010, Skora and Spradling, 2010, Liu and Lehmann, 2008, Zeitouni et al., 2007)

Eip63F1

(Ren et al., 2005)

Eip63Fa

eip63F-1

(Yi et al., 2007)

Name Synonyms

Ecdysone-induced protein 63F 1

(Zeitouni et al., 2007)

Secondary FlyBase IDs

FBgn0035474

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 55 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

47878

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P48593

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P48593

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P48593

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

47878/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004910

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004910

FlyMine - An integrated database for Drosophila genomics

FBgn0004910

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG15855

MARRVEL_MODEL - MARRVEL (model organism gene)

47878

Linkouts

BioGRID - A database of protein and genetic interactions.

71025

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0004910

DroID - A comprehensive database of gene and protein interactions.

FBgn0004910

DRSC - Results frm RNAi screens

FBgn0004910

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004910

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0004910

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG15855

Flygut - An atlas of the Drosophila adult midgut

FBgn0004910

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0004910

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC012785

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

47878

References (62)

The following external sites may use different assemblies or annotations than FlyBase.

-0.61

Report Sections