FlyBase Gene Report: Dmel\Nox

General Information

Symbol

Dmel\Nox

Species

D. melanogaster

Name

NADPH oxidase

Annotation Symbol

CG34399

Feature Type

protein_coding_gene

FlyBase ID

FBgn0085428

Gene Model Status

Current

Stock Availability

16 publicly available

Gene Summary

NADPH oxidase (Nox) encodes a protein involved in calcium flux and smooth muscle contraction during ovulation. [Date last reviewed: 2019-09-19] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

dNox

Key Links

Genomic Location

Cytogenetic map

53B2-53B4

Sequence location

2R:16,307,269..16,316,485 [+]

Recombination map

2-79

RefSeq locus

NT_033778 REGION:16307269..16316485

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables calcium ion binding

inferred from electronic annotation with InterPro:IPR002048

(InterPro Project Members, 2004-)

enables oxidoreductase activity

inferred from electronic annotation with InterPro:IPR013112, InterPro:IPR013121, InterPro:IPR017927

(InterPro Project Members, 2004-)

enables superoxide-generating NAD(P)H oxidase activity

inferred from biological aspect of ancestor with PANTHER:PTN000239643

(GO Reference Genome Project, 2011-)

enables superoxide-generating NADPH oxidase activity

inferred from sequence or structural similarity with UniProtKB:Q96PH1

(Gene Ontology Curators, 2002-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in ovulation

inferred from mutant phenotype

(Ritsick et al., 2007)

involved_in positive regulation of calcium-mediated signaling

inferred from mutant phenotype

(Ritsick et al., 2007)

involved_in positive regulation of smooth muscle contraction

inferred from mutant phenotype

(Ritsick et al., 2007)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in defense response

inferred from biological aspect of ancestor with PANTHER:PTN000239643

(GO Reference Genome Project, 2011-)

involved_in superoxide anion generation

inferred from biological aspect of ancestor with PANTHER:PTN000239643

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of NADPH oxidase complex

inferred from biological aspect of ancestor with PANTHER:PTN000239643

(GO Reference Genome Project, 2011-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001735877

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

NAD(P)H OXIDOREDUCTASES, OXYGEN AS ACCEPTOR

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

superoxide-generating NADPH oxidase activity
RHEA 63180:

Summaries

Gene Snapshot

NADPH oxidase (Nox) encodes a protein involved in calcium flux and smooth muscle contraction during ovulation. [Date last reviewed: 2019-09-19]

Gene Group (FlyBase)

NAD(P)H OXIDOREDUCTASES, OXYGEN AS ACCEPTOR -: NAD(P)H oxidoreductases with oxygen as acceptor, include dehydrogenases that oxidize NADH or NADPH with the reduction of oxygen molecule.

Summary (Interactive Fly)

generation of reactive oxygen species, Nox knockdown in mature follicle cells leads to a reduction in superoxide and to defective ovulation - Nox in required for induction of the secreted Turandot family proteins through the action of Unpaired proteins - extracellular actin detection via Nox dependent Src-family kinase-dependent cascade is means of detecting cell injury - expressed in midgut

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Nox for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A8DWJ8)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.55

Gene model reviewed during 5.50

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Nox-RB

FBtr0344889

NM_001299556

4636

1282

Nox-RC

FBtr0112650

NM_001103866

4706

1340

Nox-RD

FBtr0345378

NM_001299557

6586

1340

Nox-RE

FBtr0345379

NM_137272

4913

1340

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Nox-PB

FBpp0311201

145.8

1282

8.71

FBpp0111562

151.6

1340

8.98

FBpp0311529

151.6

1340

8.98

FBpp0311530

151.6

1340

8.98

A8DWJ8

NP_611116

AAF58016

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1340 aa isoforms: Nox-PC, Nox-PD, Nox-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nox using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.47

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Nox in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Nox

View exonic expression by tissue for Dmel\Nox

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

5740310/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0085428

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0085428

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0085428

Flygut - An atlas of the Drosophila adult midgut

FBgn0085428

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 16 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Nox

Transgenic constructs containing regulatory region of Nox

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2R)Exel6063

(Ryder, 2004.4.26)

Df(2R)Exel7142

(Ryder, 2004.4.26)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Nox^GD2030

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

Nox^GD2030

viable, with Scer\GAL4^tin.CΔ4

Nox^GD2030

viable, with Scer\GAL4^Tub.PU

Nox^RNAi.UAS.cRa

Sterility

Allele

female sterile, with Scer\GAL4^nrv1.PS

Nox^RNAi.UAS.cRa

female sterile, with Scer\GAL4^Tub.PU

Nox^RNAi.UAS.cRa

semi-sterile, with Scer\GAL4^c179

Nox^RNAi.UAS.cRa

semi-sterile, with Scer\GAL4^C855a

Nox^RNAi.UAS.cRa

Other Phenotypes

Allele

abnormal size | adult stage, with Scer\GAL4^Tub.PU

Nox^RNAi.UAS.cRa

abnormal stress response | adult stage

Nox^MI15634

abnormal stress response | adult stage, with Scer\GAL4^rn-GAL4-5

Nox^HMS00691

increased occurrence of cell division | adult stage, with Scer\GAL4^NP0001

Nox^GD2030

long lived, with Scer\GAL4^NP0001

Nox^GD2030

visible, with Scer\GAL4^pnr-MD237

Nox^GD2030

visible | adult stage

Nox^MI15634

visible | adult stage, with Scer\GAL4^rn-GAL4-5

Nox^HMS00691

Phenotype manifest in

Allele

adult gut, with Scer\GAL4^NP0001

Nox^GD2030

adult head, with Scer\GAL4^Tub.PU

Nox^RNAi.UAS.cRa

clypeus, with Scer\GAL4^Tub.PU

Nox^RNAi.UAS.cRa

ovary | adult stage, with Scer\GAL4^nrv1.PS

Nox^RNAi.UAS.cRa

ovary | adult stage, with Scer\GAL4^Tub.PU

Nox^RNAi.UAS.cRa

trichogen cell, with Scer\GAL4^pnr-MD237

Nox^GD2030

wing

Nox^MI15634

wing, with Scer\GAL4^rn-GAL4-5

Nox^HMS00691

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (47)

Hsap\NOX5

14 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Hsap\LOC118142757

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (36)

Rnor\Cybb

5 of 14

Yes

Rnor\Nox1

5 of 14

Yes

Rnor\Nox3

5 of 14

Yes

Rnor\Nox4

5 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (37)

Mmus\Cybb

5 of 14

Yes

Mmus\Nox1

5 of 14

Yes

Mmus\Nox3

5 of 14

Yes

Mmus\Nox4

4 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (29)

Xtro\nox5

8 of 13

Yes

Xtro\cybb

3 of 13

Yes

Xtro\nox1

3 of 13

Yes

3 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (36)

Drer\nox5

14 of 14

Yes

3 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (30)

Cele\bli-3

2 of 14

Yes

Cele\duox-2

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (40)

Agam\AgaP_AGAP008072

12 of 12

Yes

3 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (46)

Atha\AT1G19230

7 of 13

Yes

Atha\AT3G45810

7 of 13

Yes

Atha\AT4G25090

7 of 13

Yes

Atha\AT5G60010

7 of 13

Yes

Atha\RBOHA

7 of 13

Yes

Atha\RBOHD

7 of 13

Yes

Atha\RHD2

7 of 13

Yes

6 of 13

6 of 13

6 of 13

3 of 13

Yes

Atha\FRO2

3 of 13

Yes

Atha\FRO3

3 of 13

Yes

Atha\FRO4

3 of 13

Yes

Atha\FRO5

3 of 13

Yes

Atha\FRO6

3 of 13

Yes

Atha\FRO7

3 of 13

Yes

Atha\FRO8

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

Yes

Atha\AT3G10190

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (11)

Scer\FRE5

3 of 13

Yes

Scer\FRE7

3 of 13

Yes

Scer\AIM14

2 of 13

Yes

Scer\FRE1

2 of 13

Yes

Scer\FRE2

2 of 13

Yes

Scer\FRE3

2 of 13

Yes

Scer\FRE4

2 of 13

Yes

Scer\FRE6

2 of 13

Yes

Scer\CNB1

1 of 13

Scer\FRE8

1 of 13

Yes

Scer\FRQ1

1 of 13

Schizosaccharomyces pombe (Fission yeast) (4)

Spom\frp1

2 of 12

Yes

Spom\frp2

2 of 12

Yes

Spom\ncs1

1 of 12

Spom\SPCC830.06

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Nox. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (33)

4 of 13

2 of 13

2 of 13

2 of 13

elm

2 of 13

Cam

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Dgk

1 of 13

Eip63F-1

1 of 13

Frq1

1 of 13

Frq2

1 of 13

Nca

1 of 13

Pxd

1 of 13

Pxn

1 of 13

Pxt

1 of 13

sowi

1 of 13

sunz

1 of 13

TpnC73F

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

Nox^HMS00691

ameliorates neurodegenerative disease

modeled by ifc^KO

(Tzou et al., 2021)

Nox^HMS00429

ameliorates neurodegenerative disease

modeled by ifc^KO

(Tzou et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

NOX5; NADPH oxidase 5

14 of 14

606572

CYBB; cytochrome b-245 beta chain

3 of 14

300481

NOX1; NADPH oxidase 1

3 of 14

300225

NOX3; NADPH oxidase 3

3 of 14

607105

NOX4; NADPH oxidase 4

3 of 14

605261

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

PGRP-SD

suppressible

Nox

(Iatsenko et al., 2018)

Pink1

suppressible

Nox

(Xia et al., 2024)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0085428

MIST (protein-protein) - An integrated Molecular Interaction Database

5740310

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Detoxification of Reactive Oxygen Species

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-79

Cytogenetic map

53B2-53B4

Sequence location

2R:16,307,269..16,316,485 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

53B2-53B4

; Limits computationally determined from genome sequence between P{lacW}Lis-1^k11702&P{EP}CG8443^EP969 and P{lacW}l(2)k07824^k07824&P{lacW}veg^k03402

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-79

(FlyBase, 2016)

2-82.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (16)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

50581

y¹ v¹; P{TRiP.GLC01703}attP40

92572

y¹ v¹; P{U6.2-Nox.dgRNA}attP40

38906

y¹ v¹; P{TRiP.GL00677}attP40/CyO

61114

y¹ w^*; Mi{MIC}Nox^MI15634/SM6a

602735

w¹¹¹⁸; TI{2A-C-int::GAL4(21-881)}Nox^G4-C-int/CyO

78988

y¹ w^*; TI{CRIMIC.TG4.0}Nox^{CR00693-TG4.0}/SM6a

32433

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00429}attP2

3896R-2

v100753

v102559

v4913

w¹¹¹⁸; P{GD2030}v4913

v4914

w¹¹¹⁸; P{GD2030}v4914

More stocks available...

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (4)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI15205

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0085428

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: Nox CG15924

(FlyBase Genome Annotators, 2007)

Additional comments

Annotations CG3896 and CG15924 merged as CG34399 in release 5.2 of the genome annotation.

(FlyBase Genome Annotators, 2007)

Nomenclature History

Source for database identify of

Source for identity of: Nox CG3896

(Lee, 2006.2.23)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

CG15924

CG34399

(National Institute of Genetics Fly Stocks, 2022-, Trivedi et al., 2020, Balakrishnan et al., 2015, Choo et al., 2015, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, FlyBase Genome Annotators, 2007)

CG3896

(Choo et al., 2015, Lee, 2006.2.23, Butler et al., 2003)

DmNox

(Xiao et al., 2017)

NOX

(Basu et al., 2024, Schneider and Imler, 2021, Lang et al., 2019)

NOX-1

(Muliyil and Narasimha, 2014)

NOX4

(Johnson et al., 2020)

NOX5

(Hewitt and Degnan, 2022)

Nox

(Guo et al., 2026, Luo et al., 2025, Nagy and Buchon, 2025, Rabah et al., 2025, Černý et al., 2024, Liu et al., 2024, Liu et al., 2024, Mpamhanga and Kounatidis, 2024, Salminen et al., 2024, Vesala et al., 2024, Zeng et al., 2024, Clemente and Weavers, 2023, Ewen-Campen et al., 2023, McQuarrie et al., 2023, Neophytou et al., 2023, Voutyraki et al., 2023, Neophytou and Pitsouli, 2022, Sobrido-Cameán et al., 2022, Boumard and Bardin, 2021, Dhawan et al., 2021, Kong et al., 2021, Morris and Jasper, 2021, Sinenko et al., 2021, Fujisawa et al., 2020, Lesperance and Broderick, 2020, Li et al., 2020, Knapp et al., 2019, Meltzer et al., 2019, Reedy et al., 2019, Gene Disruption Project members, 2018-, Li et al., 2018, Croze et al., 2017, Louradour et al., 2017, Fogarty et al., 2016, Choo et al., 2015, Chartier et al., 2012, Japanese National Institute of Genetics, 2012.5.21)

Nox1

(Muliyil and Narasimha, 2014)

dNox

(Balakrishnan et al., 2015, Jones et al., 2015, Ritsick et al., 2007, Lee, 2006.2.23, Ha et al., 2005, Ha et al., 2005)

dnox

(Jones et al., 2013)

nox

(Braun et al., 2025, Gera et al., 2022)

Name Synonyms

CG15924

NADPH oxidase

(Chartier et al., 2012, Ha et al., 2005)

Secondary FlyBase IDs

FBgn0034112
FBgn0034111

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 46 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

5740310

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A8DWJ8

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A8DWJ8

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

5740310/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0085428

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0085428

FlyMine - An integrated database for Drosophila genomics

FBgn0085428

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG34399

MARRVEL_MODEL - MARRVEL (model organism gene)

5740310

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0085428

DRSC - Results frm RNAi screens

FBgn0085428

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0085428

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0085428

Flygut - An atlas of the Drosophila adult midgut

FBgn0085428

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0085428

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC033657

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

5740310

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Detoxification of Reactive Oxygen Species

References (106)

The following external sites may use different assemblies or annotations than FlyBase.

-0.47

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