Subject: 63F map update
Please update the following for the 63F region.
Eip63Fb should be called Eip63F2. Its synonym (E63-2) is correct, but it
does not encode a putative Ca2+-binding protein. It produces a single
transcript of 1.25 kb, but it's function at present is unknown, ie there
are no significant matches in the database. The accession number is
correct, but the correct reference for its cloning and sequencing is: A. J.
Andres and C. S. Thummel, Development  121:2667-2679  (1995).
Eip63Fa should be called Eip63F1. Its synonym is E63-1. and it encodes a
193 aa Ca2+-binding protein with four putative Ca2+-binding domains. It is
most similar to calmodulins with approx. 35% similarity overall. It
produces three transcripts of 2.8, 1.7, and 1.1 kb. All three are induced
by ecdysone in the salivary gland, all three share the same 5' ends, and
all three encode the same open reading frame. The accession number for
Eip63F1 is U25882, and the reference for its cloning and sequencing is the
same as above: A. J. Andres and C. S. Thummel, Development 121: 2667-2679
(1995).
Thanks for updatining the flybase info on these two genes.
Andrew Andres
Dept of Molec Pharm & Biol Chem
Northwestern University
303 E. Chicago Ave
Chicago, IL 60611
312-503-0082
Subject: Re: 63F map update
Dear Andrew,
Thank you for your updates about Eip63Fa and Eip63Fb.
Unfortunately there is a small (though not insurmountable!) problem with the
symbols you suggest.
Eip63F1 suggests that the gene maps to band 63F1, and Eip63F2 suggests that
the gene maps to band 63F2. If this is not the case, and you do not know
the cytological locations of these genes to that degree of accuracy, may I
suggest the symbols Eip63F-1 and Eip63F-2, which avoids that problem.
best wishes,
Rachel
Subject: Re: 63F map update
Dear Rachel,
I agree with your analysis and think that Eip63F-1 and Eip63F-2 are much
better names.
Thanks