FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mrjF101I.UAS.Tag:FLAG
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General Information
Symbol
Dmel\mrjF101I.UAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0319292
Feature type
allele
Associated gene
Dmel\mrj
Associated Insertion(s)
Carried in Construct
P{UAS-Flag-mrj.F101I}
Key Links
Transgenic product class
missense_variant
(Li et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Li et al., 2016)
Mutagen
in vitro construct
(Li et al., 2016)
Progenitor genotype
Carried in construct
P{UAS-Flag-mrj.F101I}
Cytology
Description

UASt regulatory sequences drive expression of a mutated mrj LD10701 cDNA which contains the amino acid replacement F101I, equivalent to the F89I mutation associated with disease in DNAJB6, a human ortholog. The protein is tagged with Tag:FLAG.

(Li et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
mrj
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Li et al., 2016)

      Direct disease model in flies has not been developed; genetic interactions in context of a disease model have been assessed.

      DNAJB6:p.Phe89Ile
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
        External database links
        ClinVar: DNAJB6_31531
        Comments concerning this variant
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference

        Co-expression of mrjScer\UAS.WT.T:Zzzz\FLAG significantly suppresses the accumulation of cytoplasmic inclusions in the indirect flight muscle seen in flies with expression of Hsap\HNRNPA2B1D290V.Scer\UAS driven by Scer\GAL4Mhc.PW; co-expression of mrjF101I.Scer\UAS.T:Zzzz\FLAG or mrjF105L.Scer\UAS.T:Zzzz\FLAG does not suppress the phenotype and indeed enhances it.

        (Li et al., 2016)
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        mrjF101I.Scer\UAS.T:Zzzz\FLAG
        mrjF101I.UAS.Tag:FLAG
        Name Synonyms
        Secondary FlyBase IDs
          References (2)