FlyBase Allele Report: Dmel\park[UAS.mCherry]

General Information

Symbol

Dmel\park^UAS.mCherry

Species

D. melanogaster

Name

FlyBase ID

FBal0319552

Feature type

allele

Associated gene

Dmel\park

Associated Insertion(s)

Carried in Construct

P{UAS-park.mCherry}

Key Links

Transgenic product class

wild_type

(Zhu et al., 2015)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Zhu et al., 2015)

Mutagen

in vitro construct

(Zhu et al., 2015)

Progenitor genotype

Carried in construct

P{UAS-park.mCherry}

Cytology

Description

UASt regulatory sequences drive expression of the park open reading frame tagged with mCherry.

(Zhu et al., 2015)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

park

Tagged with

mCherry

red fluorescent protein

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

larval somatic muscle cell | third instar larval stage, with Scer\GAL4^how-24B

(Zhu et al., 2015)

mitochondrion | third instar larval stage, with Scer\GAL4^how-24B

(Zhu et al., 2015)

Detailed Description

Statement

Reference

Ectopic expression of park^{Scer\UAS.T:Disc\RFP-mCherry} under the control of Scer\GAL4^how-24B results in mitochondrial fragmentation in third instar larval body wall muscle (i.e. smaller and rounder mitochondria compared to controls).

(Zhu et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^how-24B, park^UAS.mCherry has mitochondrion | third instar larval stage phenotype, enhanceable by Scer\GAL4^how-24B/mask^HMS01045

(Zhu et al., 2015)

Scer\GAL4^how-24B, park^UAS.mCherry has larval somatic muscle cell | third instar larval stage phenotype, enhanceable by Scer\GAL4^how-24B/mask^HMS01045

(Zhu et al., 2015)

Suppressed by

Statement

Reference

Scer\GAL4^how-24B, park^UAS.mCherry has mitochondrion | third instar larval stage phenotype, suppressible by mask^UAS.cZa/Scer\GAL4^how-24B

(Zhu et al., 2015)

Scer\GAL4^how-24B, park^UAS.mCherry has larval somatic muscle cell | third instar larval stage phenotype, suppressible by mask^UAS.cZa/Scer\GAL4^how-24B

(Zhu et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The mitochondrial fragmentation seen in body wall muscles in third instar larvae expressing park^{Scer\UAS.T:Disc\RFP-mCherry} under the control of Scer\GAL4^how-24B is exacerbated further by co-expression of mask^HMS01045.

The mitochondrial fragmentation seen in body wall muscles in third instar larvae expressing park^{Scer\UAS.T:Disc\RFP-mCherry} under the control of Scer\GAL4^how-24B is suppressed by co-expression of mask^Scer\UAS.cZa which leads to highly tangled and interconnected mitochondria.

(Zhu et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

park^{Scer\UAS.T:Disc\RFP-mCherry}

park^UAS.mCherry

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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