FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\VavΔSH2-SH3
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General Information
Symbol
Dmel\VavΔSH2-SH3
Species
D. melanogaster
Name
FlyBase ID
FBal0319566
Feature type
allele
Associated gene
Dmel\Vav
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Martín-Bermudo et al., 2015)
Progenitor genotype
Cytology
Description

41bp deletion resulting in a frameshift before the SH2 domain (30 novel amino acid residues are introduced before the stop codon).

(Martín-Bermudo et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
X:19,270,860..19,270,902 [+]
Comment:

2 nt are deleted, then 2 nt are OK and then 39 nt are deleted (41 nt deleted in total). After the frameshift, there are 30 novel amino acids followed by a stop codon.

Inserted_sequence:

CA

(Malartre, 2017.2.20)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      VavΔSH2-SH3 mutants show supernumerary cone and primary pigment cells in the pupal retina.

      (Martín-Bermudo et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      VavΔSH2-SH3
      VavΔSH2-SH3
      (Malartre, 2017.2.20)
      vavΔSH2-SH3
      (Martín-Bermudo et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)