FB2026_02 , released June 18, 2026
Allele: Dmel\VavΔSH3
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General Information
Symbol
Dmel\VavΔSH3
Species
D. melanogaster
Name
FlyBase ID
FBal0319567
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

10bp deletion resulting in a frameshift that removes the last 6 amino acids of the SH2 domain and introduces a single amino acid followed by a stop codon, thus removing the entire SH3 domain.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Comment:

10 nt are deleted at the end of the SH2 domain leading to the loss of the last 6 amino acids of the SH2 domain. The deletion causes a frameshift, after which there is one novel amino acid (R) and a stop codon.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Vast majority of ommatidia from VavΔSH3 mutants show normal numbers of cone and primary pigment cells in the pupal retina with only very few ommatidia containing extra cells.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)