FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\rictor305A
Open Close
General Information
Symbol
Dmel\rictor305A
Species
D. melanogaster
Name
FlyBase ID
FBal0319805
Feature type
allele
Associated gene
Dmel\rictor
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Jevtov et al., 2015)
Progenitor genotype
P{EPgy2}rictorEY08986
(Jevtov et al., 2015)
Cytology
Description

Approximately 1.4kb deletion that removes rictor exons 2 and 3. This generates a premature stop codon after 58 amino acid residues. Generated by imprecise excision of P{EPgy2}rictorEY08986.

(Jevtov et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:19,258,539..19,259,939 [-]
Comment:

Approximate boundaries of a ~1.4kb deletion resulting from the imprecise excision of P{EPgy2}rictorEY08986 that removes rictor exons 2 and 3.

(Jevtov et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      rictor305A/rictor305A, rictor77A/rictor305A and hemizygous rictor305A flies are viable with no obvious morphological defects, but are slightly reduced in size.

      rictor305A mutant adult males are highly sensitive to heat stress as compared with controls, becoming sluggish and paralyzed upon heat exposure at 37[o]C, and are able to recover once returned to normal temperature. These flies do not exhibit sensitivity to oxidative stress or starvation as compared to controls. rictor305A mutant larvae exhibit increased heat sensitivity, with absent or reduced mobility as compared to controls upon heat exposure at 37[o]C. In contrast to controls, mutant larvae fail to form stress granules in their hemocytes 2 hours after heat exposure.

      (Jevtov et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      rictor305A is a non-enhancer of abnormal heat stress response | adult stage phenotype of Sin1e03756

      (Jevtov et al., 2015)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Sin1e03756, rictor305A double mutants exhibit a similar level of heat sensitivity as observed in Sin1e03756 single mutants.

      (Jevtov et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      rictor305A is rescued by Scer\GAL4Tub.PU/rictorUAS.Tag:HA

      (Jevtov et al., 2015)
      Comments

      Expression of rictorScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4tub.PU rescues the heat sensitivity of rictor305A mutant flies.

      (Jevtov et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Rictor305A
      (Jevtov et al., 2015)
      rictor305A
      Name Synonyms
      Secondary FlyBase IDs
        References (1)