FB2026_02 , released June 18, 2026
Allele: Hsap\SNRPA1Q148R.UASp
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General Information
Symbol
Hsap\SNRPA1Q148R.UASp
Species
H. sapiens
Name
FlyBase ID
FBal0319841
Feature type
allele
Associated gene
Hsap\SNRPA1
Associated Insertion(s)
Carried in Construct
P{UASp-hSNRPA1.Q148R}
Key Links
Transgenic product class
missense_variant
(Wu et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Wu et al., 2016)
Mutagen
in vitro construct
(Wu et al., 2016)
Progenitor genotype
Carried in construct
P{UASp-hSNRPA1.Q148R}
Cytology
Description

UASp regulatory sequences drive expression of Hsap\SNRPA1 which has been mutated to contain the amino acid replacement Q148R.

(Wu et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
Hsap\SNRPA1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Wu et al., 2016)
      SNRPA1:p.Gln148Arg
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
      External database links
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\SNRPA1Q148R.Scer\UAS.P\T driven by Scer\GAL4bam.T:Hsim\VP16 (but not by Scer\GAL4upd1-E132 or Scer\GAL4C587) significantly reduces male fertility and testes lack mature sperm and show defects in spermatogonial development.

      (Wu et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      Hsap\SNRPA1Q148R.UASp, Scer\GAL4VP16.bam is a non-suppressor of male sterile phenotype of Scer\GAL4VP16.bam, U2ARNAi.UASp

      (Wu et al., 2016)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Hsap\SNRPA1Q148R.Scer\UAS.P\T does not rescue fertility or spermatogonial maturation defects in flies with expression of U2AdsRNA.shRNA.Scer\UAS.P\T driven by Scer\GAL4bam.T:Hsim\VP16.

      (Wu et al., 2016)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\SNRPA1Q148R.Scer\UAS.P\T
      Hsap\SNRPA1Q148R.UASp
      Name Synonyms
      Secondary FlyBase IDs
        References (2)