FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Nmnat4-7.AltReport.UAS.DsRed(Unk),AcGFP1
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General Information
Symbol
Dmel\Nmnat4-7.AltReport.UAS.DsRed(Unk),AcGFP1
Species
D. melanogaster
Name
FlyBase ID
FBal0319905
Feature type
allele
Associated gene
Dmel\Nmnat
Associated Insertion(s)
Carried in Construct
P{UAS-Nmnat.4-7.AltReport}
Key Links
Transgenic product class
Mutagen
    Nature of the Allele
    Transgenic product class
    Mutagen
    Progenitor genotype
    Carried in construct
    P{UAS-Nmnat.4-7.AltReport}
    Cytology
    Description

    UAS regulatory sequences drive expression of exons 4-7 of Nmnat with a DsRed(Unk) tag inserted in exon 5 and an AcGFP (AcGFP1) tag inserted in exon 6. This construct will produce two alternative transcripts: one containing the DsRed(Unk) sequence (proxy for splicing to RB) and one containing the AcGFP1 sequence (proxy for splicing to RA).

    (Ruan et al., 2015)
    Allele components
    Component
    Use(s)
    Regulatory region(s)
    UAS
    Encoded product / tool
    Nmnat
    Tagged with
    AcGFP1
    DsRed(Unk)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Flies with expression of Nmnat4-7.AltReport.Scer\UAS.T:Disc\RFP,T:Acoe\GFP driven in neurons by Scer\GAL4elav-C155 that are subjected to heat shock stress shift towards splicing RB; when expression is driven in glia by Scer\GAL4repo.PU, splicing is driven towards RA; ubiquitous expression driven by Scer\GAL4Act.PU leads to an overall increase in both splicing forms (RA and RB) in the brain.

        (Ruan et al., 2015)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Nmnat4-7.AltReport.Scer\UAS.T:Disc\RFP,T:Acoe\GFP
        Nmnat4-7.AltReport.UAS.DsRed(Unk),AcGFP1
        Name Synonyms
        Secondary FlyBase IDs
          References (1)