FB2026_02 , released June 18, 2026
Allele: Dmel\E(spl)mγ-HLHnull
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General Information
Symbol
Dmel\E(spl)mγ-HLHnull
Species
D. melanogaster
Name
FlyBase ID
FBal0320004
Feature type
allele
Associated gene
Dmel\E(spl)mγ-HLH
Associated Insertion(s)
TI{sfGFP}E(spl)mγ-HLHnull
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Bivik et al., 2016)
Progenitor genotype
Associated Insertion(s)
TI{sfGFP}E(spl)mγ-HLHnull
Cytology
Description

The E(spl)mγ-HLH open reading frame has been replaced by sfGFP. A loxP cassette containing a Disc\RFP3xP3.cUa marker has also been introduced 3' to the inserted sfGFP sequence.

(Bivik et al., 2016)
Allele components
Component
Use(s)
Inserted element
TI{sfGFP}
Encoded product / tool
sfGFP
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      E(spl)mγ-HLHnull/Df(3R)BSC751 mutant embryos display a significant increase in the number of Ap neurons, and display a significant increase in the number of EL neurons, as compared with controls.

      (Bivik et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      E(spl)mγ-HLHnull
      mγnull
      (Bivik et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)