FlyBase Allele Report: Dmel\ppk26[1]

General Information

Symbol

Dmel\ppk26¹

Species

D. melanogaster

Name

FlyBase ID

FBal0320034

Feature type

allele

Associated gene

Dmel\ppk26

Associated Insertion(s)

TI{TI}ppk26¹

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Guo et al., 2014)

Mutagen

Progenitor genotype

Associated Insertion(s)

TI{TI}ppk26¹

Cytology

Description

Part of the ppk26 gene, including the first exon and part of the second exon, has been replaced by a w^+mW.hs marker.

(Guo et al., 2014)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:7,456,179..7,456,895 [+]

Comment:

A deletion generated by homologous recombination. The extent of the deletion was determined from reported primer sequences.

(Guo et al., 2014)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology | larval stage | chemical conditional

(Guo et al., 2025)

abnormal pain response | larval stage

(Guo et al., 2025)

abnormal pain response | third instar larval stage

(Guo et al., 2014)

abnormal pain response | third instar larval stage (with ppk26^Gal4)

(Guo et al., 2014)

Phenotype Manifest In

larval multidendritic class IV neuron | chemical conditional

(Guo et al., 2025)

Detailed Description

Statement

Reference

The percentage of ppk26¹/ppk26¹ or ppk26^Gal4/ppk26¹ third instar larvae showing rolling behavior in response to 47mN nociceptive mechanical stimuli is significantly reduced compared to wild type; ppk26¹/ppk26¹ larvae show this reduction in response to a wide range of mechanical forces (2.5, 5, 12 and 47mN), but show normal response delay (similar to controls) in a 47[o]C thermal nociception assay.

(Guo et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

ppk26¹ has abnormal pain response | third instar larval stage phenotype, enhanceable by Piezo^KO/Piezo^KO

(Guo et al., 2014)

NOT Enhanced by

Statement

Reference

ppk26¹ has abnormal pain response | larval stage phenotype, non-enhanceable by ppk^Δ16

(Guo et al., 2025)

NOT suppressed by

Statement

Reference

ppk26¹ has abnormal pain response | larval stage phenotype, non-suppressible by ppk^Δ16

(Guo et al., 2025)

Enhancer of

Statement

Reference

ppk26¹/ppk26¹ is an enhancer of abnormal pain response | third instar larval stage phenotype of Piezo^KO

(Guo et al., 2014)

NOT Enhancer of

Statement

Reference

ppk26¹ is a non-enhancer of abnormal pain response | larval stage phenotype of ppk^Δ16

(Guo et al., 2025)

NOT Suppressor of

Statement

Reference

ppk26¹ is a non-suppressor of abnormal pain response | larval stage phenotype of ppk^Δ16

(Guo et al., 2025)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The percentage of Piezo^KO/Piezo^KO;ppk26¹/ppk26¹ double mutant third instar larvae showing rolling behavior in response to nociceptive mechanical stimuli (47mN) is significantly reduced compared to either single mutant alone.

(Guo et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

ppk26¹ is rescued by Scer\GAL4^ppk26.PG/ppk26^UAS.mCherry

(Guo et al., 2025)

ppk26¹ is rescued by ppk26^+t6.4

(Guo et al., 2014)

ppk26¹ is rescued by ppk26^UAS.cGa/Scer\GAL4^ppk26.PG

(Guo et al., 2014)

Comments

ppk26^+t6.4 or expression of ppk26^Scer\UAS.cGa driven by Scer\GAL4^ppk26.PG rescues rolling behavior in response to 47mN nociceptive mechanical stimuli in ppk26¹/ppk26¹ third instar larvae.

(Guo et al., 2014)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ppk26¹

(Liu et al., 2022, Zhang et al., 2020, Guo et al., 2014)

ppk26^KO

(Guo et al., 2025)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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