FlyBase Allele Report: Dmel\ppk26[Gal4]

General Information

Symbol

Dmel\ppk26^Gal4

Species

D. melanogaster

Name

FlyBase ID

FBal0320035

Feature type

allele

Associated gene

Dmel\ppk26

Associated Insertion(s)

TI{GAL4}ppk26^Gal4

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

ends-out gene targeting

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Guo et al., 2014)

Mutagen

ends-out gene targeting

(Guo et al., 2014)

Progenitor genotype

Associated Insertion(s)

TI{GAL4}ppk26^Gal4

Cytology

Description

Part of the ppk26 gene, including the first exon and part of the second exon, has been replaced sequence encoding a GAL4 driver followed by a w^+mW.hs marker.

(Guo et al., 2014)

Allele components

Component

Use(s)

Inserted element

TI{GAL4}

promoter trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal pain response | third instar larval stage

(Guo et al., 2014)

abnormal pain response | third instar larval stage (with ppk26¹)

(Guo et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

ppk26^Gal4 mutant adults have no difference in spiking of mechanosensory neurons of the labellar taste bristles or labellar taste pegs in response to mechanical stimuli, compared to controls.

(Zhou et al., 2019)

ppk26^Gal4 does not significantly affect neuronal morphology of class IV da neurons in larvae.

The percentage of ppk26^Gal4/ppk26^Gal4 or ppk26^Gal4/ppk26¹ third instar larvae showing rolling behavior in response to 47mN nociceptive mechanical stimuli is significantly reduced compared to wild type.

(Guo et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

ppk26^Gal4 has abnormal pain response | third instar larval stage phenotype, enhanceable by Piezo^KO/Piezo^KO

(Guo et al., 2014)

Enhancer of

Statement

Reference

ppk26^Gal4/ppk26^Gal4 is an enhancer of abnormal pain response | third instar larval stage phenotype of Piezo^KO

(Guo et al., 2014)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The percentage of Piezo^KO/Piezo^KO;ppk26^Gal4/ppk26^Gal4 double mutant third instar larvae showing rolling behavior in response to nociceptive mechanical stimuli (47mN) is significantly reduced compared to either single mutant alone.

(Guo et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

ppk26^Gal4

(Zhou et al., 2019, Guo et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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