FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pi3K92E::HsapPIK3CDDp37.UAS
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General Information
Symbol
Dmel\Pi3K92E::Hsap\PIK3CDDp37.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0320776
Feature type
allele
Associated gene
Pi3K92E::Hsap\PIK3CD
Associated Insertion(s)
Carried in Construct
PBac{UAS-Pi3K92E::Hsap\PIK3CD.Dp37}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Ejeskär et al., 2015)
Progenitor genotype
Carried in construct
PBac{UAS-Pi3K92E::Hsap\PIK3CD.Dp37}
Cytology
Description

UASt regulatory sequences drive expression of a fusion protein that consists of the N-terminal part of Pi3K92E (including the Pi3K21B binding domain) fused to the C-terminal part of the Hsap\PIK3CD p37δ isoform.

(Ejeskär et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Pi3K92E::Hsap\PIK3CD
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Over-expression of Pi3K92E::Hsap\PIK3CDDp37.Scer\UAS driven by Scer\GAL4da.PU results in significant increases in the weight of male flies (around 22% heavier than controls), due to increases in total cell number (as measured by the significant increase in the average DNA content of flies); these effects are significantly higher when expression of Pi3K92E::Hsap\PIK3CDDp37.Scer\UAS is driven, compared to expression of Pi3K92EN.Scer\UAS. Over-expression of Pi3K92E::Hsap\PIK3CDDp37.Scer\UAS driven by Scer\GAL4da.PU does not significantly alter lifespan compared to controls.

      (Ejeskär et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Pi3K92E::Hsap\PIK3CDDp37.Scer\UAS suppresses embryonic lethality seen with expression of Pi3K21BScer\UAS.T:Ivir\HA1 driven by Scer\GAL4da.PU.

      Co-expression of Pi3K92E::Hsap\PIK3CDDp37.Scer\UAS suppresses the small body phenotype in larvae with expression of Pi3K21BScer\UAS.T:Ivir\HA1 driven by Scer\GAL4da.PU, but larvae remain developmentally delayed and retain fat body abnormalities.

      (Ejeskär et al., 2015)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Pi3K92E::Hsap\PIK3CDDp37.Scer\UAS
      Pi3K92E::Hsap\PIK3CDDp37.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)