FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ogadel.1
Open Close
General Information
Symbol
Dmel\Ogadel.1
Species
D. melanogaster
Name
FlyBase ID
FBal0321420
Feature type
allele
Associated gene
Dmel\Oga
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Akan et al., 2016)
Mutagen
P-element activity
(Akan et al., 2016)
Progenitor genotype
P{SUPor-P}OgaKG04950
(Akan et al., 2016)
Cytology
Description

Excision of the progenitor insertion (that is inserted 100 bp upstream of the Oga ATG start site), removing 657 bp of the Oga gene including the promoter, first exon, and a portion of the second exon. This is predicted to remove 171 amino acids at the N terminus of the protein sequence, corresponding to over half of the predicted O-GlcNAcase domain including nearly all of the catalytically important residues. Transcript levels are reduced to near zero at the deleted locus, though the rest of the gene is transcribed at levels comparable with wild type - therefore it is possible that a truncated protein containing an intact C-terminal domain, including the pseudo-histone acetyltransferase domain, is still made.

(Akan et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:21,219,130..21,219,786 [+]
Comment:

Estimated boundaries of a 657 bp deletion reported to start upstream of Oga and remove 171 amino acids of the protein.

(Akan et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ogadel.1 homozygous mutants are viable and fertile but the females display semi-penetrant oogenesis defect and lay significantly fewer eggs per day when mated with either Ogadel.1 mutant or wild-type male. The females have smaller degenerate ovaries compared to wild-type.

      Ogadel.1/Df(3R)ED10838 as well as Ogadel.1/Df(3R)ED10845 mutant flies show normal fertility.

      (Akan et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Ogadel.1 is rescued by Scer\GAL4Act.PU/OgaUAS.cKa.Tag:HA

      (Akan et al., 2021)

      Ogadel.1 is rescued by Scer\GAL4nanos.PU/OgaUAS.cKa.Tag:HA

      (Akan et al., 2016)

      Ogadel.1 is rescued by Scer\GAL4Act.PU/OgaUAS.cKa.Tag:HA

      (Akan et al., 2016)
      Comments

      Expression of OgaScer\UAS.cKa.T:Ivir\HA1 under the control of either Scer\GAL4Act.PU or Scer\GAL4nos.PU rescues the impaired oogenesis as well as defective ovary morphology characteristic for Ogadel.1 homozygous females - the number of eggs laid by Ogadel.1 mutant females ectopically expressing OgaScer\UAS.cKa.T:Ivir\HA1 is even higher than in wild-type.

      (Akan et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      OGAdel.1
      (Na et al., 2022)
      Ogadel.1
      (Na et al., 2022)
      ogadel.1
      (Akan et al., 2021, Akan et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)