FB2026_02 , released June 18, 2026
Allele: Dmel\SMC6Tag:HA
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General Information
Symbol
Dmel\SMC6Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0321612
Feature type
allele
Associated gene
Dmel\SMC6
Associated Insertion(s)
Carried in Construct
P{SMC6-6xHA}
Key Links
Transgenic product class
wild_type
(Tran et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Tran et al., 2016)
Mutagen
in vitro construct
(Tran et al., 2016)
Progenitor genotype
Carried in construct
P{SMC6-6xHA}
Cytology
Description

Contains the jnj coding region plus 409bp of upstream and 154bp of downstream sequence (starting from the 5'UTR and 3'UTR respectively). Six copies of the Tag:HA tag have been inserted at the C-terminal end of the open reading frame.

(Tran et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
SMC6
Encoded product / tool
SMC6
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      epitope tag
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      oogenesis
      germarium region 1
      (Tran et al., 2016)
      germarium region 2a
      (Tran et al., 2016)
      germarium region 2b
      (Tran et al., 2016)
      germarium region 3
      (Tran et al., 2016)
      female germline cyst
      (Tran et al., 2016)
      oogenesis stage S1 -- S14
      oocyte
      (Tran et al., 2016)
      oogenesis stage S2 -- S3
      nurse cell
      (Tran et al., 2016)
      oogenesis stage S8
      nurse cell
      (Tran et al., 2016)
      Additional Information
      Statement
      Reference

      Expression is observed in all germarial stages in the germline cysts. It is present in oocytes throughout oogenesis and is visible in nurse cells in stages S2-3 and not again until stage S8.

      (Tran et al., 2016)
       
      Marker for
      Reflects expression of
      dany
      (Tran et al., 2016)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of jnjT:Ivir\HA1 does not lead to a significant difference in survival of embryos from these mothers.

      (Tran et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      SMC6Tag:HA partially rescues SMC6Δ35

      (Tran et al., 2016)
      Comments

      Expression of jnjT:Ivir\HA1 partially rescues the lethality, developmental arrest, nuclear fallout, and anaphase-bridge formation phenotypes exhibited by embryos from jnjΔ35/jnjΔ35 mothers, and partially rescues the X chromosome non-disjunction, impaired double strand break repair, pachytene arrest and delayed karyosome dynamics phenotypes exhibited in jnjΔ35/jnjΔ35 female gonads.

      (Tran et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      SMC66xHA
      (Tran et al., 2016)
      SMC6Tag:HA
      jnjT:Ivir\HA1
      jnjTag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)