FB2026_02 , released June 18, 2026
Allele: Dmel\iclnUAS.cBa
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General Information
Symbol
Dmel\iclnUAS.cBa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Borg
FlyBase ID
FBal0321622
Feature type
allele
Associated gene
Dmel\icln
Associated Insertion(s)
Carried in Construct
P{UAS-icln.B}
Key Links
Transgenic product class
cDNA
(Borg et al., 2016)
wild_type
(Borg et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Borg et al., 2016)
wild_type
(Borg et al., 2016)
Mutagen
in vitro construct
(Borg et al., 2016)
Progenitor genotype
Carried in construct
P{UAS-icln.B}
Cytology
Description

UASt regulatory sequences drive expression of the full-length icln coding sequence (derived from the SD10511 cDNA clone).

(Borg et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
icln
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of either one or two copies of iclnScer\UAS.cBa under the control of any of the following: Scer\GAL4c179, Scer\GAL4how-24B or Scer\GAL4da.PU leads to lethality at both 29[o]C and 25[o]C, in the case of the Scer\GAL4G7 partial lethality is observed at 25[o]C while the flies are completely lethal at 29[o]C. Expression under Scer\GAL4elav.PU or Scer\GAL4RapGAP1-OK6 does not significantly decrease adult viability compared to controls at either of the two temperatures. When two copies of iclnScer\UAS.cBa are used, expression under Scer\GAL4Mef2.PR at 29[o]C is also lethal and adult viability is reduced at 25[o]C.

      Adult flies expressing iclnScer\UAS.cBa under the control of Scer\GAL4Mef2.PR are completely flightless and show 'droopy' wing posture, they also display significant drop in locomotor activity both during day and at night compared to controls.

      Expression of iclnScer\UAS.cBa under the control of Scer\GAL4how-24B leads to an increased length (length/width axial ratio) of pupae compared to controls.

      (Borg et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Suppressed by
      Statement
      Reference

      Scer\GAL4Mef2.PR, iclnUAS.cBa has flightless phenotype, suppressible by Gem3ΔN.UAS, Scer\GAL4Mef2.PR

      (Borg et al., 2016)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Flies expressing both iclnScer\UAS.cBa and Gem3ΔN.Scer\UAS under the control of Scer\GAL4Mef2.PR are completely lethal.

      (Borg et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      iclnUAS.cBa/Scer\GAL4Mef2.PR rescues iclnNIG.4924R

      (Borg et al., 2016)
      Partially rescues

      iclnUAS.cBa/Scer\GAL4da.PU partially rescues iclnNIG.4924R

      (Borg et al., 2016)
      Comments

      The lethality of flies expressing iclnNIG.4924R under the control of Scer\GAL4da.PU and the flightless phenotype observed in flies expressing iclnScer\UAS.cBa under the Scer\GAL4Mef2.PR driver is partially rescued and fully rescued, respectively, by co-expression of iclnScer\UAS.cBa.

      (Borg et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      iclnScer\UAS.cBa
      iclnUAS.cBa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Borg
      Secondary FlyBase IDs
        References (2)