FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cicΔC2.UAS.Tag:HA
Open Close
General Information
Symbol
Dmel\cicΔC2.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0321698
Feature type
allele
Associated gene
Dmel\cic
Associated Insertion(s)
Carried in Construct
P{UAS-cic.ΔC2.HA}
Key Links
Transgenic product class
inframe_deletion
(Jin et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Jin et al., 2015)
Mutagen
in vitro construct
(Jin et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-cic.ΔC2.HA}
Cytology
Description

UAS regulatory sequences drive expression of cic carrying a deletion of the MAPK docking site-C2 motif. The protein is tagged with Tag:HA.

(Jin et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
cic
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The regeneration-associated proliferation normally observed in adult midgut upon Pseudomonas entomophila enteric infection is inhibited by cicΔC2.Scer\UAS.T:Ivir\HA1 expression: the growth of somatic intestinal stem cell flip-out clones expressing cicΔC2.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4esg-NP5130 in which all the progeny of the intestinal stem cells born during the regeneration period are visibly marked (using tub-Gal80[ts] to limit the time of expression/clone induction) is significantly reduced compared to controls.

      (Jin et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increase in the adult midgut intestinal stem cell proliferation characteristic for flies expressing either pntP1.Scer\UAS or pntP2.Scer\UASunder the control of Scer\GAL4esg-NP5130 (using tub-Gal80[ts] to limit the time of the transgene expression) is not suppressed by co-expression of cicΔC2.Scer\UAS.T:Ivir\HA1.

      The overgrowth and increased mitotic rate of intestinal stem cell somatic flip-out clones expressing btl::EgfrScer\UAS.T:λ\cI-DD under the control of Scer\GAL4esg-NP5130 (using tub-Gal80[ts] to limit the time of expression/clone induction) in the adult midgut is suppressed by co-expression of cicΔC2.Scer\UAS.T:Ivir\HA1; the number of mitotic cells per adult midgut is even lower than in wild-type.

      (Jin et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      cicΔC2.Scer\UAS.T:Ivir\HA1
      cicΔC2.UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (2)