FlyBase Allele Report: Dmel\Trl[519.UAS]

General Information

Symbol

Dmel\Trl^519.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0321717

Feature type

allele

Associated gene

Dmel\Trl

Associated Insertion(s)

Carried in Construct

P{UAS-Trl.519}

Key Links

Transgenic product class

wild_type

(Tsai et al., 2016)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Tsai et al., 2016)

Mutagen

in vitro construct

(Tsai et al., 2016)

Progenitor genotype

Carried in construct

P{UAS-Trl.519}

Cytology

Description

UAS regulates expression of the 519aa isoform of Trl.

(Tsai et al., 2016)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Trl

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage, with Scer\GAL4^ey.PU

(Tsai et al., 2016)

abnormal size | third instar larval stage, with Scer\GAL4^ey.PU

(Tsai et al., 2016)

Phenotype Manifest In

eye | adult stage, with Scer\GAL4^ey.PU

(Tsai et al., 2016)

eye disc | third instar larval stage, with Scer\GAL4^ey.PU

(Tsai et al., 2016)

eye disc posterior compartment | third instar larval stage, with Scer\GAL4^ey.PU

(Tsai et al., 2016)

ommatidium | adult stage, with Scer\GAL4^ey.PU

(Tsai et al., 2016)

polytene chromosome, with Scer\GAL4^dpp.PU

(Tsai et al., 2016)

Detailed Description

Statement

Reference

Expression of Trl^519.Scer\UAS under the control of Scer\GAL4^dpp.PU results in reduced size of polytene chromosomes in the salivary gland.

Expression of Trl^519.Scer\UAS under the control of Scer\GAL4^ey.PU in eye imaginal tissues leads to reduced size of the third instar eye disc, with the region posterior to the morphogenetic furrow showing impaired development; and reduced size of the adult eye and reduced number of ommatidia, but no significant difference in the average space per ommatidium, as compared to controls.

(Tsai et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^ey.PU, Trl^519.UAS has abnormal size | adult stage phenotype, suppressible | partially by E(bx)^Nurf301-9/E(bx)[+]

(Tsai et al., 2016)

Scer\GAL4^ey.PU, Trl^519.UAS has abnormal size | adult stage phenotype, suppressible | partially by Nelf-A[+]/Nelf-A^KG09483