FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Nelf-AKG09483
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General Information
Symbol
Dmel\Nelf-AKG09483
Species
D. melanogaster
Name
FlyBase ID
FBal0148197
Feature type
allele
Associated gene
Dmel\Nelf-A
Associated Insertion(s)
P{SUPor-P}Nelf-AKG09483
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{SUPor-P}Nelf-AKG09483
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{SUPor-P}
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Nelf-AKG09483/+ does not significantly affect the size of the adult eye, as compared to wild type.

      (Tsai et al., 2016)

      Hemizygotes appear morphologically normal at the end of embryogenesis and hatch as first instar larvae. These larvae survive for several days, but do not increase in size.

      More than 50% of embryos derived from homozygous female germline clones arrest prior to the cellular blastoderm stage and show abnormal nuclear morphology. The remaining embryos proceed through the blastoderm stage and gastrulate normally, but then almost always arrest during germband retraction with head defects and incomplete dorsal closure.

      (Wang et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Nelf-A[+]/Nelf-AKG09483 is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4ey.PU, Trl519.UAS

      (Tsai et al., 2016)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Nelf-A[+]/Nelf-AKG09483 is a suppressor | partially of eye | adult stage phenotype of Scer\GAL4ey.PU, Trl519.UAS

      (Tsai et al., 2016)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Nelf-AKG09483/+ partially restores the eye size of flies expressing Trl519.Scer\UAS under the control of Scer\GAL4dpp.PU.

      (Tsai et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Excision of the P{SUPor-P}Nelf-AKG09483 insertion reverts the lethality over Df(3R)e-R1 but does not revert the recessive lethality of the P{SUPor-P}Nelf-AKG09483 chromosome, indicating the presence of a second site lethal mutation on the chromosome.

      (Wang et al., 2010)

      Separable from: a second site lethal mutation.

      (Wang et al., 2010)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      CG5874KG09483
      NELF-AKG09483
      NELF-AKG
      (Wang et al., 2010)
      Nelf-AKG09483
      (Ngian et al., 2021, Tsai et al., 2016)
      nelf-aKG09483
      (Grice et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)