FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\POSHHMC05588
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General Information
Symbol
Dmel\POSHHMC05588
Species
D. melanogaster
Name
FlyBase ID
FBal0321873
Feature type
allele
Associated gene
Dmel\POSH
Associated Insertion(s)
Carried in Construct
P{TRiP.HMC05588}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
in vitro construct
(Perkins et al., 2009)
Progenitor genotype
Carried in construct
P{TRiP.HMC05588}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Perkins et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMC05588
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  frontotemporal dementia
      modeled by Hsap\CHMP2BIntron5.UAS
      (West et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of POSHHMC05588 under the control of Scer\GAL4nSyb.PS does not lead to any synaptic overgrowth at neuromuscular junction (assessed by the number of boutons and NMJ length) in third instar larvae.

      (West et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The neuromuscular junction synaptic overgrowth and larval locomotion deficits along with the abnormal brain accumulations of POSH protein induced by Scer\GAL4nSyb.PS-driven expression of Hsap\CHMP2BIntron5.UAS is ameliorated by co-expression of POSHHMC05588.

      (West et al., 2018)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      POSHHMC05588
      Name Synonyms
      Secondary FlyBase IDs
        References (3)