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General Information
Symbol
Dmel\trrK662X
Species
D. melanogaster
Name
FlyBase ID
FBal0323345
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

A1887792T

Amino acid change:

K641term | trr-PC; K662term | trr-PD

Reported amino acid change:

K662term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: K662term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

trrK662X mutant somatic clones show a growth advantage over the wild-type cells as the trrK662X mutant tissue is relatively overrepresented in the mosaic adult eyes. However, the overall size of the adult mosaic eyes or eyes composed almost entirely by the mutant cells (generated by mitotic recombination with a chromosome bearing a recessive cell-lethal mutation, thus removing the wild-type twin spots) is decreased. The trrK662X clones display a disrupted ommatidial lattice (misoriented ommatidia, missing photoreceptor cells), giving the mutant tissue a rough appearance. Extra inter-ommatidial cells are observed in trrK662X clones in the pupal retina. trrK662X mutant clones are overrepresented also in the third instar larval eye discs and induce increased apoptosis in the mosaic discs - at least some of the dying cells are wild-type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

trr[+]/trrK662X is a suppressor | partially of visible | adult stage phenotype of N55e11

trr[+]/trrK662X is a suppressor | partially of visible | adult stage phenotype of Ser1

Phenotype Manifest In
Suppressor of
Statement
Reference

trr[+]/trrK662X is a suppressor | partially of wing margin phenotype of N55e11

trr[+]/trrK662X is a suppressor | partially of wing margin phenotype of Ser1

Additional Comments
Genetic Interactions
Statement
Reference

The wing-notching phenotype characteristic for either N55e11/+ or Ser1/+ adult flies is partially suppressed by combination with a single copy of trrK662X.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)