FB2026_02 , released June 18, 2026
Allele: Dmel\LUBELCC-SS
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General Information
Symbol
Dmel\LUBELCC-SS
Species
D. melanogaster
Name
FlyBase ID
FBal0323582
Feature type
allele
Associated gene
Dmel\LUBEL
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Asaoka et al., 2016)
Mutagen
CRISPR/Cas9
(Asaoka et al., 2016)
Progenitor genotype
Cytology
Description

The zinc ion-coordinating Cys residues (C2690/C2693) in the RING2 domain of LUBEL have been substituted with serine (S) to create a catalytically dead LUBEL protein.

(Asaoka et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:6,761,269..6,761,269 [-]
Nucleotide change:

G6761269C

Reported nucleotide change:

G?C

Amino acid change:

C2690S | LUBEL-PE; C2649S | LUBEL-PG; C2637S | LUBEL-PI; C2596S | LUBEL-PJ

Reported amino acid change:

C?S

Comment:

One of two Cys to Ser mutations in zinc ion-coordinating Cys residues in the RING2 domain of LUBEL.

(Asaoka et al., 2016)
point_mutation
2L:6,761,260..6,761,260 [-]
Nucleotide change:

G6761260C

Reported nucleotide change:

G?C

Amino acid change:

C2693S | LUBEL-PE; C2652S | LUBEL-PG; C2640S | LUBEL-PI; C2599S | LUBEL-PJ

Reported amino acid change:

C?S

Comment:

One of two Cys to Ser mutations in zinc ion-coordinating Cys residues in the RING2 domain of LUBEL.

(Asaoka et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Neither the adult muscle morphology nor functionality is affected in both young and aged adult LUBELCC-SS mutant flies (climbing ability of aged adults is normal) and they show normal survival rate upon infection with either Escherichia coli (Gram-negative) or Micrococcus luteus (Gram-positive), however the longevity of LUBELCC-SS homozygous mutant flies is reduced compared to wild-type controls and they also display decreased survival rate in a heat-shock stress assay.

      (Asaoka et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      LUBEL CC/SS
      (Asaoka et al., 2016)
      LUBEL CC2690/2693SS
      (Asaoka et al., 2016)
      LUBELCC-SS
      LUBELCC/SS
      (Kawaguchi et al., 2026)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)