FB2026_03 , released September 17, 2026
Allele: Dmel\LUBELdelR2
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General Information
Symbol
Dmel\LUBELdelR2
Species
D. melanogaster
Name
FlyBase ID
FBal0323583
Feature type
allele
Associated gene
Dmel\LUBEL
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Asaoka et al., 2016)
Mutagen
CRISPR/Cas9
(Asaoka et al., 2016)
Progenitor genotype
Cytology
Description

An indel mutation with an early stop codon at amino acid 2719 due to a frameshift, resulting in deletion of the RING2 domain and creation of a catalytically dead LUBEL protein.

(Asaoka et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
sequence_alteration
2L:6,761,259..6,761,259 [-]
Comment:

An indel starting at this location leads to a frameshift and results in early translation termination. The exact sequence of the indel was not reported.

(Asaoka et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The longevity of LUBELdelR2 homozygous mutant adults is reduced compared to wild-type controls and they also display decreased survival rate in a heat-shock stress assay. However, LUBELdelR2 mutant flies show normal survival rate upon infection with either Escherichia coli (Gram-negative) or Micrococcus luteus (Gram-positive) and the climbing ability of aged mutants is also normal.

      (Asaoka et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      LUBEL delR2
      (Asaoka et al., 2016)
      LUBEL delRING2
      (Asaoka et al., 2016)
      LUBELDelR2
      (Kawaguchi et al., 2026)
      LUBELdelR2
      Name Synonyms
      Secondary FlyBase IDs
        References (2)