FB2026_02 , released June 18, 2026
Allele: Dmel\sxcD955A.UAS
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General Information
Symbol
Dmel\sxcD955A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0323903
Feature type
allele
Associated gene
Dmel\sxc
Associated Insertion(s)
Carried in Construct
M{UAS-sxc.D955A}
Key Links
Transgenic product class
missense_variant
(Mariappa et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Mariappa et al., 2015)
Mutagen
in vitro construct
(Mariappa et al., 2015)
Progenitor genotype
Carried in construct
M{UAS-sxc.D955A}
Cytology
Description

UAS regulatory sequences drive expression of sxc carrying the amino acid replacement D955A (this mutation has been shown to result in a protein with no catalytic activity in vitro).

(Mariappa et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
sxc
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing sxcD955A.Scer\UAS under the control of Scer\GAL4tub.PU partially rescue the lethality of sxc1/sxc6 transheterozygotes but the majority of surviving adults show wing defects, including ectopic veins, notches and blistering; the progeny of sxcD955A.Scer\UAS-rescued sxc1/sxc6 females dies before reaching second larval instar (crossed with either sxcD955A.Scer\UAS-rescued sxc1/sxc6 males) or adulthood (crossed with wild-type males) due to maternal effect.

      (Mariappa et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      sxcD955A.UAS/Scer\GAL4Tub.PU partially rescues sxc6/sxc1

      (Mariappa et al., 2015)
      Comments

      The expression of sxcD955A.Scer\UAS under the control of Scer\GAL4tub.PU partially rescues the pharate adult stage lethality of sxc1/sxc6 heterozygotes, but the majority of surviving adults show wing defects, including ectopic veins, notches and blistering; the progeny of sxcD955A.Scer\UAS-rescued sxc1/sxc6 females dies before reaching second larval instar (crossed with either sxcD955A.Scer\UAS-rescued sxc1/sxc6 males) or adulthood (crossed with wild-type males) due to maternal effect.

      (Mariappa et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      sxcD955A.Scer\UAS
      sxcD955A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)