FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\APPAβ40.UAS.cUa
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General Information
Symbol
Hsap\APPAβ40.UAS.cUa
Species
H. sapiens
Name
FlyBase ID
FBal0324200
Feature type
allele
Associated gene
Hsap\APP
Associated Insertion(s)
Carried in Construct
P{UAS-Aβ40.U}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(FlyBase Curators, 2025-)
Progenitor genotype
Carried in construct
P{UAS-Aβ40.U}
Cytology
Description

UAS regulatory sequences drive expression of the Aβ40 peptide.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\APP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Alzheimer's disease 1
      CEC
      (Wacker et al., 2014)
      CEA
      (Fang et al., 2012)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  Alzheimer's disease 1
      is exacerbated by Zzzz\VHHKW1.UAS.Tag:SS(nec),Tag:MYC
      (Wacker et al., 2014)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\APPAβ40.Scer\UAS.cUa under the control of Scer\GAL4GMR.PF does not result in significant photoreceptor degeneration after two days intense light stimulation, as measured by ERG response amplitudes.

      (Williamson and Hiesinger, 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Flies co-expressing Vha100-1GD12710 and Hsap\APPAβ40.Scer\UAS.cUa under the control of Scer\GAL4GMR.PF and exposed to two days intense light stimulation show a significantly reduced ERG response amplitude.

      (Williamson and Hiesinger, 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\APPAβ40.Scer\UAS.cUa
      Hsap\APPAβ40.UAS.cUa
      Name Synonyms
      Secondary FlyBase IDs
        References (5)