FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\MAPTUAS.2N4R.cSMa
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General Information
Symbol
Hsap\MAPTUAS.2N4R.cSMa
Species
H. sapiens
Name
FlyBase ID
FBal0324787
Feature type
allele
Associated gene
Hsap\MAPT
Associated Insertion(s)
Carried in Construct
P{UAS-hTau.2N4R.SM}
Also Known As
UAS-htau
Key Links
Transgenic product class
cDNA
(Sheik Mohideen et al., 2015)
wild_type
(Sheik Mohideen et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Sheik Mohideen et al., 2015)
wild_type
(Sheik Mohideen et al., 2015)
Mutagen
in vitro construct
(Sheik Mohideen et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-hTau.2N4R.SM}
Cytology
Description

UASt regulatory sequences drive expression of a cDNA that encodes the 2N4R isoform of Hsap\MAPT.

(Sheik Mohideen et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\MAPT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  tauopathy
      CEA
      (Tsuda et al., 2017, Sheik Mohideen et al., 2015)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  tauopathy
      is exacerbated by Hsap\APP3-42.E3Q.UAS.Tag:SS(rPENK)
      (Tsuda et al., 2017)
      exacerbates  Alzheimer's disease 1
      modeled by Hsap\APP3-42.E3Q.UAS.Tag:SS(rPENK)
      (Tsuda et al., 2017)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\MAPTScer\UAS.2N4R.cSMa driven by Scer\GAL4elav-C155 leads to significant climbing defects, which are stronger when the animals are kept in light conditions instead of in darkness.

      Expression of Hsap\MAPTScer\UAS.2N4R.cSMa driven by Scer\GAL4Mef2.247 leads to significant olfactive memory defects, which are stronger when animals are kept in darkness instead of in light conditions.

      (Sheik Mohideen et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\MAPTScer\UAS.2N4R.cSMa
      Hsap\MAPTUAS.2N4R.cSMa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)