FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\APP3-42.E3Q.UAS.Tag:SS(rPENK)
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General Information
Symbol
Hsap\APP3-42.E3Q.UAS.Tag:SS(rPENK)
Species
H. sapiens
Name
FlyBase ID
FBal0365877
Feature type
allele
Associated gene
Hsap\APP
Associated Insertion(s)
Carried in Construct
P{UAS-Aβ3-42.E3Q}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Tsuda et al., 2017)
Progenitor genotype
Carried in construct
P{UAS-Aβ3-42.E3Q}
Cytology
Description

UASt regulatory sequences drive expression of a mutant Aβ peptide (3-42, E3Q) that is tagged at the N-terminal end with a Tag:SS(rPENK) signal sequence.

(Tsuda et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\APP
Tagged with
Tag:SS(rPENK)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Alzheimer's disease 1
      CEA
      (Tsuda et al., 2017)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  Alzheimer's disease 1
      is ameliorated by Ire1f02170
      (Tsuda et al., 2017)
      is ameliorated by Xbp1k13803
      (Tsuda et al., 2017)
      is ameliorated by crc1
      (Tsuda et al., 2017)
      is ameliorated by Atf6c05057
      (Tsuda et al., 2017)
      is ameliorated by BacA\p35UAS.cUa
      (Tsuda et al., 2017)
      is exacerbated by Hsap\MAPTUAS.2N4R.cSMa
      (Tsuda et al., 2017)
      exacerbates  tauopathy
      modeled by Hsap\MAPTUAS.2N4R.cSMa
      (Tsuda et al., 2017)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hsap\APP3-42.E3Q.UAS.Tag:SS(rPENK)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)