FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\TuspG
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General Information
Symbol
Dmel\TuspG
Species
D. melanogaster
Name
FlyBase ID
FBal0325062
Feature type
allele
Associated gene
Dmel\Tusp
Associated Insertion(s)
TI{GAL4}TuspG
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Yoon et al., 2017)
Mutagen
ends-out gene targeting
(Yoon et al., 2017)
Progenitor genotype
Associated Insertion(s)
TI{GAL4}TuspG
Cytology
Description

The first exon of the Tusp coding sequence (amino acid residues 1-96) have been replaced by sequence encoding a GAL4 driver, resulting in expression of GAL4 under the control of the endogenous Tusp regulatory sequences. A w+mW.hs marker has also been inserted downstream of the GAL4 sequence.

(Yoon et al., 2017)
Allele components
Component
Use(s)
Inserted element
TI{GAL4}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3R:27,615,395..27,615,490 [+]
Comment:

The first coding exon of Tusp has been deleted and replaced with GAL4 coding sequences.

(Yoon et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      In contrast to wild-type controls, TuspG homozygous as well as TuspG/Df(3R)Tusp-D transheterozygous adult flies display heat-shock (40[o]C, 5min) induced paralysis (indicative of neuronal function defects) and require up to 20 min to recover.

      (Yoon et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      TuspG is rescued by Scer\GAL4Tusp-G/TuspUAS.cYa

      (Yoon et al., 2017)
      Comments

      The heat-shock induced paralytic phenotype characteristic for TuspG homozygous adults is rescued by expression of TuspScer\UAS.cYa under the control of Scer\GAL4Tusp-G (= the inherent Gal4 in the TuspG allele).

      (Yoon et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      TuspG
      (Yoon et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)